Target：B4GT6

Fields：Sphingolipid metabolism;Metabolic pathways

Gene Name：B4GALT6

Protein Name：Beta-1,4-galactosyltransferase 6 (Beta-1,4-GalTase 6) (Beta4Gal-T6) (b4Gal-T6) (EC 2.4.1.-) (UDP-Gal:beta-GlcNAc beta-1,4-galactosyltransferase 6) (UDP-galactose:beta-N-acetylglucosamine beta-1,4-gala

Human Gene Id：9331

Human Swiss Prot No：Q9UBX8

Mouse Swiss Prot No：Q9WVK5

Rat Swiss Prot No：O88419

Immunogen：Synthesized peptide derived from part region of human protein

Specificity：B4GT6 Polyclonal Antibody detects endogenous levels of protein.

Formulation：Liquid in PBS containing 50% glycerol, and 0.02% sodium azide.

Source：Polyclonal, Rabbit,IgG

Dilution：WB 1:500-2000 ELISA 1:5000-20000

Purification：The antibody was affinity-purified from rabbit antiserum by affinity-chromatography using epitope-specific immunogen.

Concentration：1 mg/ml

Storage Stability：-15°C to -25°C/1 year(Do not lower than -25°C)

Observed Band(KD)：42kD

Background： This gene is one of seven beta-1,4-galactosyltransferase (beta4GalT) genes. They encode type II membrane-bound glycoproteins that appear to have exclusive specificity for the donor substrate UDP-galactose; all transfer galactose in a beta1,4 linkage to similar acceptor sugars: GlcNAc, Glc, and Xyl. Each beta4GalT has a distinct function in the biosynthesis of different glycoconjugates and saccharide structures. As type II membrane proteins, they have an N-terminal hydrophobic signal sequence that directs the protein to the Golgi apparatus and which then remains uncleaved to function as a transmembrane anchor. By sequence similarity, the beta4GalTs form four groups: beta4GalT1 and beta4GalT2, beta4GalT3 and beta4GalT4, beta4GalT5 and beta4GalT6, and beta4GalT7. The enzyme encoded by this gene is a lactosylceramide synthase important for glycolipid biosynthesis. [provided by RefSeq, Ju

Function：catalytic activity:UDP-galactose + glucosylceramide = UDP + lactosylceramide.,cofactor:Manganese or magnesium or calcium.,enzyme regulation:Inhibited by EDTA.,function:Required for the biosynthesis of glycosphingolipids.,online information:Beta-1,4-galactosyltransferase 6,online information:GlycoGene database,pathway:Protein modification; protein glycosylation.,similarity:Belongs to the glycosyltransferase 7 family.,subcellular location:Trans cisternae of Golgi stack.,tissue specificity:High expression in brain and adrenal gland, lower in liver, lung, colon and peripheral white blood cells.,

Subcellular Location：Golgi apparatus, Golgi stack membrane ; Single-pass type II membrane protein. Trans cisternae of Golgi stack. .

Expression：High expression in brain and adrenal gland, lower in liver, lung, colon and peripheral white blood cells.