Target：MCHR1
Fields：Neuroactive ligand-receptor interaction
Gene Name：MCHR1 GPR24 SLC1
Protein Name：Melanin-concentrating hormone receptor 1 (MCH receptor 1) (MCH-R1) (MCHR-1) (G-protein coupled receptor 24) (MCH-1R) (MCH1R) (MCHR) (SLC-1) (Somatostatin receptor-like protein)
Human Gene Id：2847
Human Swiss Prot No：Q99705
Mouse Swiss Prot No：Q8JZL2
Rat Swiss Prot No：P97639
Immunogen：Synthesized peptide derived from part region of human protein
Specificity：MCHR1 Polyclonal Antibody detects endogenous levels of protein.
Formulation：Liquid in PBS containing 50% glycerol, and 0.02% sodium azide.
Source：Polyclonal, Rabbit,IgG
Dilution：WB 1:500-2000 ELISA 1:5000-20000
Purification：The antibody was affinity-purified from rabbit antiserum by affinity-chromatography using epitope-specific immunogen.
Concentration：1 mg/ml
Storage Stability：-15°C to -25°C/1 year(Do not lower than -25°C)
Observed Band(KD)：46kD
Background：melanin concentrating hormone receptor 1(MCHR1) Homo sapiens The protein encoded by this gene, a member of the G protein-coupled receptor family 1, is an integral plasma membrane protein which binds melanin-concentrating hormone. The encoded protein can inhibit cAMP accumulation and stimulate intracellular calcium flux, and is probably involved in the neuronal regulation of food consumption. Although structurally similar to somatostatin receptors, this protein does not seem to bind somatostatin. [provided by RefSeq, Jul 2008],
Function：caution:It is uncertain whether Met-1, Met-6 or Met-70 is the initiator.,function:Receptor for melanin-concentrating hormone, coupled to both G proteins that inhibit adenylyl cyclase and G proteins that activate phosphoinositide hydrolysis.,similarity:Belongs to the G-protein coupled receptor 1 family.,subunit:Interacts with NCDN.,tissue specificity:Highest level in brain, particularly in the frontal cortex and hypothalamus, lower levels in the liver and heart.,
Subcellular Location：Cell membrane; Multi-pass membrane protein.
Expression：Highest level in brain, particularly in the frontal cortex and hypothalamus, lower levels in the liver and heart.
