Target：GLMN

Fields：Shigellosis

Gene Name：GLMN FAP48 FAP68 VMGLOM

Protein Name：Glomulin (FK506-binding protein-associated protein) (FAP) (FKBP-associated protein)

Human Gene Id：11146

Human Swiss Prot No：Q92990

Mouse Swiss Prot No：Q8BZM1

Immunogen：Synthesized peptide derived from human protein . at AA range: 80-160

Specificity：GLMN Polyclonal Antibody detects endogenous levels of protein.

Formulation：Liquid in PBS containing 50% glycerol, and 0.02% sodium azide.

Source：Polyclonal, Rabbit,IgG

Dilution：WB 1:500-2000 ELISA 1:5000-20000

Purification：The antibody was affinity-purified from rabbit antiserum by affinity-chromatography using epitope-specific immunogen.

Concentration：1 mg/ml

Storage Stability：-15°C to -25°C/1 year(Do not lower than -25°C)

Observed Band(KD)：65kD

Background：glomulin, FKBP associated protein(GLMN) Homo sapiens This gene encodes a phosphorylated protein that is a member of a Skp1-Cullin-F-box-like complex. The protein is essential for normal development of the vasculature and mutations in this gene have been associated with glomuvenous malformations, also called glomangiomas. Multiple splice variants encoding different isoforms have been found for this gene. [provided by RefSeq, Feb 2016],

Function：disease:Defects in GLMN are the cause of glomuvenous malformations (GVMs) [MIM:138000]. GVMs are characterized by the presence of smooth-muscle-like glomus cells in the media surrounding distended vascular lumens.,function:Essential for normal development of the vasculature. May represent a naturally occurring ligand of the immunophilins FKBP59 and FKBP12. May function as an membrane anchoring protein. Isoform 1 may stimulate the p70S6K pathway. Isoform 2 may inhibit cell proliferation and increase IL2 production.,miscellaneous:Rapamycin and FK506 abolish the interaction in a dose dependent manner.,PTM:Phosphorylated on tyrosine residues.,subunit:Monomer. Isoform 1 interacts with notphosphorylated MET and is released upon receptor phosphorylation. Isoform 2 interacts with FKBP59 and FKBP12. Isoform 1 is part of a SCF-like complex consisting of CUL7, RBX1, SKP1, FBXW8 and GLMN isoform 1.,

Subcellular Location：intracellular,cytoplasm,cullin-RING ubiquitin ligase complex,Cul2-RING ubiquitin ligase complex,Cul3-RING ubiquitin ligase complex,Cul4A-RING E3 ubiquitin ligase complex,

Expression：Ubiquitous.