Target：MEF-2D

Fields：cGMP-PKG signaling pathway;Apelin signaling pathway;Parathyroid hormone synthesis, secretion and action

Gene Name：MEF2D

Protein Name：Myocyte-specific enhancer factor 2D

Human Gene Id：4209

Human Swiss Prot No：Q14814

Mouse Swiss Prot No：Q63943

Rat Gene Id：81518

Rat Swiss Prot No：O89038

Immunogen：The antiserum was produced against synthesized peptide derived from human MEF2D. AA range:410-459

Specificity：MEF-2D Polyclonal Antibody detects endogenous levels of MEF-2D protein.

Formulation：Liquid in PBS containing 50% glycerol, 0.5% BSA and 0.02% sodium azide.

Source：Polyclonal, Rabbit,IgG

Dilution：IHC 1:100 - 1:300. ELISA: 1:5000.. IF 1:50-200

Purification：The antibody was affinity-purified from rabbit antiserum by affinity-chromatography using epitope-specific immunogen.

Concentration：1 mg/ml

Storage Stability：-15°C to -25°C/1 year(Do not lower than -25°C)

Other Name：MEF2D;Myocyte-specific enhancer factor 2D

Molecular Weight(Da)：56kD

Background： This gene is a member of the myocyte-specific enhancer factor 2 (MEF2) family of transcription factors. Members of this family are involved in control of muscle and neuronal cell differentiation and development, and are regulated by class II histone deacetylases. Fusions of the encoded protein with Deleted in Azoospermia-Associated Protein 1 (DAZAP1) due to a translocation have been found in an acute lymphoblastic leukemia cell line, suggesting a role in leukemogenesis. The encoded protein may also be involved in Parkinson disease and myotonic dystrophy. Alternative splicing results in multiple transcript variants. [provided by RefSeq, Oct 2012],

Function：developmental stage:Present in myotubes and also in undifferentiated myoblasts.,domain:The beta domain, missing in a number of isoforms, is required for enhancement of transcriptional activity.,function:Transcriptional activator which binds specifically to the MEF2 element, 5'-YTA[AT](4)TAR-3', found in numerous muscle-specific, growth factor- and stress-induced genes. Mediates cellular functions not only in skeletal and cardiac muscle development, but also in neuronal differentiation and survival. Plays diverse roles in the control of cell growth, survival and apoptosis via p38 MAPK signaling in muscle-specific and/or growth factor-related transcription. Plays a critical role in the regulation of neuronal apoptosis.,PTM:Acetylated on Lys-439 by CREBBP. Deacetylated by SIRT1.,PTM:Phosphorylated on Ser-444 by CDK5 is required for Lys-439 sumoylation and inhibits transcriptional activity.

Subcellular Location：Nucleus . Translocated by HDAC4 to nuclear dots.

Expression： Blood,Brain,Epithelium,Eye,Myocardium,Testis,