Target：B2L10

Gene Name：BCL2L10 BCLB

Protein Name：Bcl-2-like protein 10 (Bcl2-L-10) (Anti-apoptotic protein NrH) (Apoptosis regulator Bcl-B)

Human Gene Id：10017

Human Swiss Prot No：Q9HD36

Mouse Swiss Prot No：Q9Z0F3

Rat Swiss Prot No：Q99M66

Immunogen：Synthesized peptide derived from human protein . at AA range: 70-150

Specificity：B2L10 Polyclonal Antibody detects endogenous levels of protein.

Formulation：Liquid in PBS containing 50% glycerol, and 0.02% sodium azide.

Source：Polyclonal, Rabbit,IgG

Dilution：WB 1:500-2000 ELISA 1:5000-20000

Purification：The antibody was affinity-purified from rabbit antiserum by affinity-chromatography using epitope-specific immunogen.

Concentration：1 mg/ml

Storage Stability：-15°C to -25°C/1 year(Do not lower than -25°C)

Observed Band(KD)：21kD

Background： The protein encoded by this gene belongs to the BCL-2 protein family. BCL-2 family members form hetero- or homodimers and act as anti- or pro-apoptotic regulators that are involved in a wide variety of cellular activities. The protein encoded by this gene contains conserved BH4, BH1 and BH2 domains. This protein can interact with other members of BCL-2 protein family including BCL2, BCL2L1/BCL-X(L), and BAX. Overexpression of this gene has been shown to suppress cell apoptosis possibly through the prevention of cytochrome C release from the mitochondria, and thus activating caspase-3 activation. The mouse counterpart of this protein is found to interact with Apaf1 and forms a protein complex with Caspase 9, which suggests the involvement of this protein in APAF1 and CASPASE 9 related apoptotic pathway. [provided by RefSeq, Jul 2008],

Function：function:Promotes cell survival. Suppresses apoptosis induced by BAX but not BAK.,similarity:Belongs to the Bcl-2 family.,subunit:Binds to Bcl-2, Bcl-X and BAX. Interacts with APAF1.,tissue specificity:Widely expressed in adult tissues. Preferentially expressed in the lungs, the liver and the kidneys.,

Subcellular Location：Mitochondrion . Nucleus membrane . Endoplasmic reticulum . Cytoplasm, cytoskeleton, spindle . Localizes to mitochondria-associated endoplasmic reticulum membranes (MAMs) (PubMed:27995898). Localization to MAMs is greatly reduced under apoptotic stress conditions (PubMed:27995898). .

Expression：Widely expressed in adult tissues. Preferentially expressed in lung, liver and kidney.