Target：ATG9B

Fields：Autophagy - other;Mitophagy - animal;Autophagy - animal

Gene Name：ATG9B APG9L2 NOS3AS

Protein Name：Autophagy-related protein 9B (APG9-like 2) (Nitric oxide synthase 3-overlapping antisense gene protein) (Protein sONE)

Human Gene Id：285973

Human Swiss Prot No：Q674R7

Mouse Swiss Prot No：Q6EBV9

Immunogen：Synthesized peptide derived from part region of human protein

Specificity：ATG9B Polyclonal Antibody detects endogenous levels of protein.

Formulation：Liquid in PBS containing 50% glycerol, and 0.02% sodium azide.

Source：Polyclonal, Rabbit,IgG

Dilution：WB 1:500-2000 ELISA 1:5000-20000

Purification：The antibody was affinity-purified from rabbit antiserum by affinity-chromatography using epitope-specific immunogen.

Concentration：1 mg/ml

Storage Stability：-15°C to -25°C/1 year(Do not lower than -25°C)

Observed Band(KD)：101kD

Background： This gene functions in the regulation of autophagy, a lysosomal degradation pathway. This gene also functions as an antisense transcript in the posttranscriptional regulation of the endothelial nitric oxide synthase 3 gene, which has 3' overlap with this gene on the opposite strand. Mutations in this gene and disruption of the autophagy process have been associated with multiple cancers. Alternative splicing results in multiple transcript variants. [provided by RefSeq, Sep 2012],

Function：function:Plays a role in autophagy.,induction:By hypoxia, leading to inhibit NOS3 expression.,miscellaneous:ATG9B gene is located on the opposite DNA strand of the NOS3 gene at chromosome 7q36. The genes are oriented in a tail-to-tail configuration and the mRNAs encoding ATG9B and NOS3 are complementary for 662 nucleotides. ATG9B transcription may a role in NOS3 transcription regulation.,similarity:Belongs to the ATG9 family.,tissue specificity:Highly expressed in placenta (trophoblast cells) and pituitary gland. Not expressed in vascular endothelial.,

Subcellular Location：Preautophagosomal structure membrane ; Multi-pass membrane protein . Under amino acid starvation or rapamycin treatment, redistributes from a juxtanuclear clustered pool to a dispersed peripheral cytosolic pool (PubMed:18936157). The starvation-induced redistribution depends on ULK1 and ATG13 (PubMed:18936157). .

Expression：Highly expressed in placenta (trophoblast cells) and pituitary gland. Not expressed in vascular endothelial.