Target：BMP-3A
Fields：Cytokine-cytokine receptor interaction
Gene Name：BMP3
Protein Name：Bone morphogenetic protein 3
Human Gene Id：651
Human Swiss Prot No：P12645
Mouse Gene Id：110075
Mouse Swiss Prot No：Q8BHE5
Rat Gene Id：25667
Rat Swiss Prot No：P49002
Immunogen：The antiserum was produced against synthesized peptide derived from the C-terminal region of human BMP3. AA range:421-470
Specificity：BMP-3A Polyclonal Antibody detects endogenous levels of BMP-3A protein.
Formulation：Liquid in PBS containing 50% glycerol, 0.5% BSA and 0.02% sodium azide.
Source：Polyclonal, Rabbit,IgG
Dilution：WB 1:500 - 1:2000. IHC: 1:100-1:300. ELISA: 1:20000.. IF 1:50-200
Purification：The antibody was affinity-purified from rabbit antiserum by affinity-chromatography using epitope-specific immunogen.
Concentration：1 mg/ml
Storage Stability：-15°C to -25°C/1 year(Do not lower than -25°C)
Other Name：BMP3;BMP3A;Bone morphogenetic protein 3;BMP-3;Bone morphogenetic protein 3A;BMP-3A;Osteogenin
Observed Band(KD)：53kD
Background： This gene encodes a secreted ligand of the TGF-beta (transforming growth factor-beta) superfamily of proteins. Ligands of this family bind various TGF-beta receptors leading to recruitment and activation of SMAD family transcription factors that regulate gene expression. The encoded preproprotein is proteolytically processed to generate each subunit of the disulfide-linked homodimer. This protein suppresses osteoblast differentiation, and negatively regulates bone density, by modulating TGF-beta receptor availability to other ligands. [provided by RefSeq, Jul 2016],
Function：function:Negatively regulates bone density. Antagonizes the ability of certain osteogenic BMPs to induce osteoprogenitor differentitation and ossification.,induction:Highly expressed in fracture tissue, particularly in osteoblasts, osteoclasts and chondroblasts.,online information:Bone morphogenetic protein 3 entry,similarity:Belongs to the TGF-beta family.,subunit:Homodimer; disulfide-linked.,tissue specificity:Expressed in adult and fetal cartilage.,
Subcellular Location：Secreted.
Expression：Expressed in adult and fetal cartilage.
