Target：MDHC
Fields：Citrate cycle (TCA cycle);Cysteine and methionine metabolism;Pyruvate metabolism;Glyoxylate and dicarboxylate metabolism;Metabolic pathways;Carbon metabolism;Proximal tubule bicarbonate reclamation
Gene Name：MDH1 MDHA
Protein Name：Malate dehydrogenase, cytoplasmic (EC 1.1.1.37) (Cytosolic malate dehydrogenase) (Diiodophenylpyruvate reductase) (EC 1.1.1.96)
Human Gene Id：4190
Human Swiss Prot No：P40925
Mouse Swiss Prot No：P14152
Rat Swiss Prot No：O88989
Immunogen：Synthesized peptide derived from part region of human protein
Specificity：MDHC Polyclonal Antibody detects endogenous levels of protein.
Formulation：Liquid in PBS containing 50% glycerol, and 0.02% sodium azide.
Source：Polyclonal, Rabbit,IgG
Dilution：WB 1:500-2000 ELISA 1:5000-20000
Purification：The antibody was affinity-purified from rabbit antiserum by affinity-chromatography using epitope-specific immunogen.
Concentration：1 mg/ml
Storage Stability：-15°C to -25°C/1 year(Do not lower than -25°C)
Observed Band(KD)：36kD
Background： This gene encodes an enzyme that catalyzes the NAD/NADH-dependent, reversible oxidation of malate to oxaloacetate in many metabolic pathways, including the citric acid cycle. Two main isozymes are known to exist in eukaryotic cells: one is found in the mitochondrial matrix and the other in the cytoplasm. This gene encodes the cytosolic isozyme, which plays a key role in the malate-aspartate shuttle that allows malate to pass through the mitochondrial membrane to be transformed into oxaloacetate for further cellular processes. Alternatively spliced transcript variants have been found for this gene. A recent study showed that a C-terminally extended isoform is produced by use of an alternative in-frame translation termination codon via a stop codon readthrough mechanism, and that this isoform is localized in the peroxisomes. Pseudogenes have been identified on chromosomes X and 6. [provided by RefSeq,
Function：catalytic activity:(S)-malate + NAD(+) = oxaloacetate + NADH.,online information:Malate dehydrogenase entry,similarity:Belongs to the LDH/MDH superfamily. MDH type 2 family.,subunit:Homodimer.,
Subcellular Location：Cytoplasm.
Expression： Brain,Cajal-Retzius cell,Heart,Placenta,T-cell,
