Target：MDA-7

Fields：Cytokine-cytokine receptor interaction;Viral protein interaction with cytokine and cytokine receptor;JAK-STAT signaling pathway

Gene Name：IL24

Protein Name：Interleukin-24

Human Gene Id：11009

Human Swiss Prot No：Q13007

Mouse Gene Id：93672

Mouse Swiss Prot No：Q925S4

Rat Gene Id：170819

Rat Swiss Prot No：Q9JI24

Immunogen：The antiserum was produced against synthesized peptide derived from the Internal region of human IL24. AA range:131-180

Specificity：MDA-7 Polyclonal Antibody detects endogenous levels of MDA-7 protein.

Formulation：Liquid in PBS containing 50% glycerol, 0.5% BSA and 0.02% sodium azide.

Source：Polyclonal, Rabbit,IgG

Dilution：WB 1:500 - 1:2000. IHC: 1:100-1:300. ELISA: 1:20000.. IF 1:50-200

Purification：The antibody was affinity-purified from rabbit antiserum by affinity-chromatography using epitope-specific immunogen.

Concentration：1 mg/ml

Storage Stability：-15°C to -25°C/1 year(Do not lower than -25°C)

Other Name：IL24;MDA7;ST16;Interleukin-24;IL-24;Melanoma differentiation-associated gene 7 protein;MDA-7;Suppression of tumorigenicity 16 protein

Observed Band(KD)：24kD

Background： This gene encodes a member of the IL10 family of cytokines. It was identified as a gene induced during terminal differentiation in melanoma cells. The protein encoded by this gene can induce apoptosis selectively in various cancer cells. Overexpression of this gene leads to elevated expression of several GADD family genes, which correlates with the induction of apoptosis. The phosphorylation of mitogen-activated protein kinase 14 (MAPK7/P38), and heat shock 27kDa protein 1 (HSPB2/HSP27) are found to be induced by this gene in melanoma cells, but not in normal immortal melanocytes. Alternatively spliced transcript variants encoding distinct isoforms have been reported. [provided by RefSeq, Jul 2008],

Function：caution:The sequence shown here is derived from an Ensembl automatic analysis pipeline and should be considered as preliminary data.,function:Has antiproliferative properties on melanoma cells and may contribute to terminal cell differentiation.,online information:Interleukin-24 entry,similarity:Belongs to the IL-10 family.,tissue specificity:Up-regulated in melanoma cells induced to terminally differentiate.,

Subcellular Location：Secreted .

Expression：Up-regulated in melanoma cells induced to terminally differentiate.