Target：ARHGAP23

Gene Name：ARHGAP23

Protein Name：Rho GTPase-activating protein 23

Human Gene Id：57636

Human Swiss Prot No：Q9P227

Mouse Swiss Prot No：Q69ZH9

Immunogen：Synthesized peptide derived from ARHGAP23 . at AA range: 470-550

Specificity：ARHGAP23 Polyclonal Antibody detects endogenous levels of ARHGAP23 protein.

Formulation：Liquid in PBS containing 50% glycerol, 0.5% BSA and 0.02% sodium azide.

Source：Polyclonal, Rabbit,IgG

Dilution：WB 1:500-2000 IHC 1:100 - 1:300. ELISA: 1:40000.. IF 1:50-200

Purification：The antibody was affinity-purified from rabbit antiserum by affinity-chromatography using epitope-specific immunogen.

Concentration：1 mg/ml

Storage Stability：-15°C to -25°C/1 year(Do not lower than -25°C)

Other Name：ARHGAP23;KIAA1501;Rho GTPase-activating protein 23;Rho-type GTPase-activating protein 23

Molecular Weight(Da)：162kD

Background： The RHO (see ARHA; MIM 165390) family of small GTPases are involved in signal transduction through transmembrane receptors, and they are inactive in the GDP-bound form and active in the GTP-bound form. GTPase-activating proteins, such as ARHGAP23, inactivate RHO family proteins by stimulating their hydrolysis of GTP (Katoh and Katoh, 2004 [PubMed 15254754]).[supplied by OMIM, Mar 2008],

Function：function:GTPase activator for the Rho-type GTPases by converting them to an inactive GDP-bound state.,similarity:Contains 1 PDZ (DHR) domain.,similarity:Contains 1 PH domain.,similarity:Contains 1 Rho-GAP domain.,tissue specificity:Expressed in placenta, prostate, hippocampus and brain medulla. Also expressed in brain tumor, salivary gland tumor, head and neck tumor.,

Subcellular Location：cytosol,extracellular exosome,

Expression：Expressed in placenta, prostate, hippocampus and brain medulla. Also expressed in brain tumor, salivary gland tumor, head and neck tumor.