Target：ARHG8

Gene Name：NET1 ARHGEF8

Protein Name：Neuroepithelial cell-transforming gene 1 protein (Proto-oncogene p65 Net1) (Rho guanine nucleotide exchange factor 8)

Human Gene Id：10276

Human Swiss Prot No：Q7Z628

Mouse Swiss Prot No：Q9Z206

Immunogen：Synthesized peptide derived from human protein . at AA range: 230-310

Specificity：ARHG8 Polyclonal Antibody detects endogenous levels of protein.

Formulation：Liquid in PBS containing 50% glycerol, and 0.02% sodium azide.

Source：Polyclonal, Rabbit,IgG

Dilution：WB 1:500-2000 ELISA 1:5000-20000

Purification：The antibody was affinity-purified from rabbit antiserum by affinity-chromatography using epitope-specific immunogen.

Concentration：1 mg/ml

Storage Stability：-15°C to -25°C/1 year(Do not lower than -25°C)

Observed Band(KD)：65kD

Background： This gene is part of the family of Rho guanine nucleotide exchange factors. Members of this family activate Rho proteins by catalyzing the exchange of GDP for GTP. The protein encoded by this gene interacts with RhoA within the cell nucleus and may play a role in repairing DNA damage after ionizing radiation. Pseudogenes of this gene are located on the long arms of chromosomes 1, 7 and 18. Alternative splicing results in multiple transcript variants that encode different protein isoforms. [provided by RefSeq, Jul 2012],

Function：function:Acts as guanine nucleotide exchange factor (GEF) for RhoA GTPase. May be involved in activation of the SAPK/JNK pathway.,induction:By TGF-beta.,similarity:Contains 1 DH (DBL-homology) domain.,similarity:Contains 1 PH domain.,subunit:Interacts with RHOA in its GTP- and GDP-bound states, and with CDC42 in its GTP-bound state. Interacts with the PDZ 1 domain of BAIAP1.,tissue specificity:Widely expressed.,

Subcellular Location：Cytoplasm . Nucleus .

Expression：Widely expressed.