Target：MCM3

Fields：DNA replication;Cell cycle

Gene Name：MCM3

Protein Name：DNA replication licensing factor MCM3

Human Gene Id：4172

Human Swiss Prot No：P25205

Mouse Swiss Prot No：P25206

Immunogen：The antiserum was produced against synthesized peptide derived from the Internal region of human MCM3. AA range:641-690

Specificity：MCM3 Polyclonal Antibody detects endogenous levels of MCM3 protein.

Formulation：Liquid in PBS containing 50% glycerol, 0.5% BSA and 0.02% sodium azide.

Source：Polyclonal, Rabbit,IgG

Dilution：WB 1:500 - 1:2000. IHC: 1:100-300 ELISA: 1:20000.. IF 1:50-200

Purification：The antibody was affinity-purified from rabbit antiserum by affinity-chromatography using epitope-specific immunogen.

Concentration：1 mg/ml

Storage Stability：-15°C to -25°C/1 year(Do not lower than -25°C)

Other Name：MCM3;DNA replication licensing factor MCM3;DNA polymerase alpha holoenzyme-associated protein P1;P1-MCM3;RLF subunit beta;p102

Observed Band(KD)：89kD

Background： The protein encoded by this gene is one of the highly conserved mini-chromosome maintenance proteins (MCM) that are involved in the initiation of eukaryotic genome replication. The hexameric protein complex formed by MCM proteins is a key component of the pre-replication complex (pre_RC) and may be involved in the formation of replication forks and in the recruitment of other DNA replication related proteins. This protein is a subunit of the protein complex that consists of MCM2-7. It has been shown to interact directly with MCM5/CDC46. This protein also interacts with and is acetylated by MCM3AP, a chromatin-associated acetyltransferase. The acetylation of this protein inhibits the initiation of DNA replication and cell cycle progression. Two transcript variants encoding different isoforms have been found for this gene. [provided by RefSeq, Jul 2012],

Function：function:Acts as a factor that allows the DNA to undergo a single round of replication per cell cycle. Required for DNA replication and cell proliferation.,miscellaneous:Associated with the replication-specific DNA polymerase alpha.,PTM:Phosphorylated upon DNA damage, probably by ATM or ATR.,similarity:Belongs to the MCM family.,similarity:Contains 1 MCM domain.,

Subcellular Location：Nucleus . Chromosome . Associated with chromatin before the formation of nuclei and detaches from it as DNA replication progresses. .

Expression： Cervix,Coronary artery,Epithelium,Lymph,Osteosarcoma,Pancre