Target：GIPR

Fields：cAMP signaling pathway;Neuroactive ligand-receptor interaction

Gene Name：GIPR

Protein Name：Gastric inhibitory polypeptide receptor

Human Gene Id：2696

Human Swiss Prot No：P48546

Mouse Swiss Prot No：Q0P543

Immunogen：The antiserum was produced against synthesized peptide derived from human GIPR. AA range:93-142

Specificity：GIPR Polyclonal Antibody detects endogenous levels of GIPR protein.

Formulation：Liquid in PBS containing 50% glycerol, 0.5% BSA and 0.02% sodium azide.

Source：Polyclonal, Rabbit,IgG

Dilution：WB 1:500 - 1:2000. IHC 1:100 - 1:300. IF 1:200 - 1:1000. ELISA: 1:20000. Not yet tested in other applications.

Purification：The antibody was affinity-purified from rabbit antiserum by affinity-chromatography using epitope-specific immunogen.

Concentration：1 mg/ml

Storage Stability：-15°C to -25°C/1 year(Do not lower than -25°C)

Other Name：GIPR;Gastric inhibitory polypeptide receptor;GIP-R;Glucose-dependent insulinotropic polypeptide receptor

Observed Band(KD)：53kD

Background： This gene encodes a G-protein coupled receptor for gastric inhibitory polypeptide (GIP), which was originally identified as an activity in gut extracts that inhibited gastric acid secretion and gastrin release, but subsequently was demonstrated to stimulate insulin release in the presence of elevated glucose. Mice lacking this gene exhibit higher blood glucose levels with impaired initial insulin response after oral glucose load. Defect in this gene thus may contribute to the pathogenesis of diabetes. [provided by RefSeq, Oct 2011],

Function：function:This is a receptor for GIP. The activity of this receptor is mediated by G proteins which activate adenylyl cyclase.,similarity:Belongs to the G-protein coupled receptor 2 family.,

Subcellular Location：Cell membrane; Multi-pass membrane protein.

Expression： Colon,G-protein coupled receptors,Pancreas,