Target：ANGP4

Fields：MAPK signaling pathway;Ras signaling pathway;Rap1 signaling pathway;HIF-1 signaling pathway;PI3K-Akt signaling pathway

Gene Name：ANGPT4 ANG3 ANG4

Protein Name：Angiopoietin-4 (ANG-4) (Angiopoietin-3) (ANG-3)

Human Gene Id：51378

Human Swiss Prot No：Q9Y264

Mouse Swiss Prot No：Q9WVH6

Immunogen：Synthesized peptide derived from human protein . at AA range: 150-230

Specificity：ANGP4 Polyclonal Antibody detects endogenous levels of protein.

Formulation：Liquid in PBS containing 50% glycerol, and 0.02% sodium azide.

Source：Polyclonal, Rabbit,IgG

Dilution：WB 1:500-2000 ELISA 1:5000-20000

Purification：The antibody was affinity-purified from rabbit antiserum by affinity-chromatography using epitope-specific immunogen.

Concentration：1 mg/ml

Storage Stability：-15°C to -25°C/1 year(Do not lower than -25°C)

Observed Band(KD)：55kD

Background： Angiopoietins are proteins with important roles in vascular development and angiogenesis. All angiopoietins bind with similar affinity to an endothelial cell-specific tyrosine-protein kinase receptor. The mechanism by which they contribute to angiogenesis is thought to involve regulation of endothelial cell interactions with supporting perivascular cells. The protein encoded by this gene functions as an agonist and is an angiopoietin. [provided by RefSeq, Jul 2008],

Function：caution:Was originally (PubMed:10218486) called angiopoietin-3.,function:Binds to tyrosine-protein kinase receptor TIE2 and activates it.,similarity:Contains 1 fibrinogen C-terminal domain.,tissue specificity:Highly expressed in the lung with much lower levels found in other tissues.,

Subcellular Location：Secreted .

Expression：Highly expressed in the lung with much lower levels found in other tissues.