Target：BAGE5

Gene Name：BAG5

Protein Name：BAG family molecular chaperone regulator 5

Human Gene Id：9529

Human Swiss Prot No：Q9UL15

Mouse Gene Id：70369

Mouse Swiss Prot No：Q8CI32

Rat Gene Id：366734

Rat Swiss Prot No：Q5QJC9

Immunogen：Synthesized peptide derived from BAGE5 . at AA range: 30-110

Specificity：BAGE5 Polyclonal Antibody detects endogenous levels of BAGE5 protein.

Formulation：Liquid in PBS containing 50% glycerol, 0.5% BSA and 0.02% sodium azide.

Source：Polyclonal, Rabbit,IgG

Dilution：WB 1:500 - 1:2000. ELISA: 1:5000. Not yet tested in other applications.

Purification：The antibody was affinity-purified from rabbit antiserum by affinity-chromatography using epitope-specific immunogen.

Concentration：1 mg/ml

Storage Stability：-15°C to -25°C/1 year(Do not lower than -25°C)

Other Name：BAG5;KIAA0873;BAG family molecular chaperone regulator 5;BAG-5;Bcl-2-associated athanogene 5

Observed Band(KD)：51kD

Background： The protein encoded by this gene is a member of the BAG1-related protein family. BAG1 is an anti-apoptotic protein that functions through interactions with a variety of cell apoptosis and growth related proteins including BCL-2, Raf-protein kinase, steroid hormone receptors, growth factor receptors and members of the heat shock protein 70 kDa family. This protein contains a BAG domain near the C-terminus, which could bind and inhibit the chaperone activity of Hsc70/Hsp70. Three transcript variants encoding two different isoforms have been found for this gene. [provided by RefSeq, Jul 2008],

Function：function:Inhibits the chaperone activity of HSP70/HSC70 by promoting substrate release. Inhibits both auto-ubiquitination of PARK2 and ubiquitination of target proteins by PARK2.,similarity:Contains 4 BAG domains.,subunit:Binds to the ATPase domain of HSP70/HSC chaperones. Binds PARK2.,

Subcellular Location：nucleus,mitochondrion,cytosol,membrane,inclusion body,perinuclear region of cytoplasm,

Expression： Brain,