Target：E-Ras

Gene Name：ERAS

Protein Name：GTPase Eras

Human Gene Id：3266

Human Swiss Prot No：Q7Z444

Mouse Swiss Prot No：Q7TN89

Immunogen：The antiserum was produced against synthesized peptide derived from human ERAS. AA range:184-233

Specificity：E-Ras Polyclonal Antibody detects endogenous levels of E-Ras protein.

Formulation：Liquid in PBS containing 50% glycerol, 0.5% BSA and 0.02% sodium azide.

Source：Polyclonal, Rabbit,IgG

Dilution：WB 1:500 - 1:2000. IF 1:200 - 1:1000. ELISA: 1:20000. Not yet tested in other applications.

Purification：The antibody was affinity-purified from rabbit antiserum by affinity-chromatography using epitope-specific immunogen.

Concentration：1 mg/ml

Storage Stability：-15°C to -25°C/1 year(Do not lower than -25°C)

Other Name：ERAS;HRAS2;HRASP;GTPase ERas;E-Ras;Embryonic stem cell-expressed Ras

Observed Band(KD)：25kD

Background： This gene encodes a constitutively active member of the small GTPase Ras protein family. The encoded protein activates the phosphatidylinositol 3-kinase signal transduction pathway in undifferentiated stem cells, but is not expressed in differentiated cells. This gene may be involved in cancer and chemotherapy resistance. [provided by RefSeq, Dec 2012],

Function：enzyme regulation:Alternate between an inactive form bound to GDP and an active form bound to GTP. Activated by a guanine nucleotide-exchange factor (GEF) and inactivated by a GTPase-activating protein (GAP).,function:Ras proteins bind GDP/GTP and possess intrinsic GTPase activity. Plays an important role in the tumor-like growth properties of embryonic stem cells.,similarity:Belongs to the small GTPase superfamily. Ras family.,subunit:Interacts with PIK3CD.,

Subcellular Location：Cell membrane ; Lipid-anchor ; Cytoplasmic side .

Expression： Brain,