Target：ERAP2

Gene Name：ERAP2 LRAP

Protein Name：Endoplasmic reticulum aminopeptidase 2 (EC 3.4.11.-) (Leukocyte-derived arginine aminopeptidase) (L-RAP)

Human Gene Id：64167

Human Swiss Prot No：Q6P179

Immunogen：Synthesized peptide derived from part region of human protein

Specificity：ERAP2 Polyclonal Antibody detects endogenous levels of protein.

Formulation：Liquid in PBS containing 50% glycerol, and 0.02% sodium azide.

Source：Polyclonal, Rabbit,IgG

Dilution：WB 1:500-2000 ELISA 1:5000-20000

Purification：The antibody was affinity-purified from rabbit antiserum by affinity-chromatography using epitope-specific immunogen.

Concentration：1 mg/ml

Storage Stability：-15°C to -25°C/1 year(Do not lower than -25°C)

Observed Band(KD)：105kD

Background： This gene encodes a zinc metalloaminopeptidase of the M1 protease family that resides in the endoplasmic reticulum and functions in N-terminal trimming antigenic epitopes for presentation by major histocompatibility complex (MHC) class I molecules. Certain mutations in this gene are associated with the inflammatory arthritis syndrome ankylosing spondylitis and pre-eclampsia. This gene is located adjacent to a closely related aminopeptidase gene on chromosome 5. [provided by RefSeq, Jul 2016],

Function：cofactor:Binds 1 zinc ion per subunit.,function:Aminopeptidase that plays a central role in peptide trimming, a step required for the generation of most HLA class I-binding peptides. Peptide trimming is essential to customize longer precursor peptides to fit them to the correct length required for presentation on MHC class I molecules. Preferentially hydrolyzes the basic residues Arg and Lys.,induction:By IFN-gamma.,miscellaneous:Defects in the expression of this gene may cause improper antigen processing, possibly leading to favor tumor escape from the immune surveillance.,PTM:N-glycosylated.,similarity:Belongs to the peptidase M1 family.,subunit:Heterodimer; with ERAP1.,tissue specificity:Ubiquitously expressed. Highly expressed in spleen and leukocytes.,

Subcellular Location：Endoplasmic reticulum membrane ; Single-pass type II membrane protein .

Expression：Ubiquitously expressed. Highly expressed in spleen and leukocytes.