Target：Eps8L2

Gene Name：EPS8L2

Protein Name：Epidermal growth factor receptor kinase substrate 8-like protein 2

Human Gene Id：64787

Human Swiss Prot No：Q9H6S3

Mouse Gene Id：98845

Mouse Swiss Prot No：Q99K30

Immunogen：The antiserum was produced against synthesized peptide derived from human ES8L2. AA range:1-50

Specificity：Eps8L2 Polyclonal Antibody detects endogenous levels of Eps8L2 protein.

Formulation：Liquid in PBS containing 50% glycerol, 0.5% BSA and 0.02% sodium azide.

Source：Polyclonal, Rabbit,IgG

Dilution：WB 1:500 - 1:2000. IHC 1:100 - 1:300. IF 1:200 - 1:1000. ELISA: 1:40000. Not yet tested in other applications.

Purification：The antibody was affinity-purified from rabbit antiserum by affinity-chromatography using epitope-specific immunogen.

Concentration：1 mg/ml

Storage Stability：-15°C to -25°C/1 year(Do not lower than -25°C)

Other Name：EPS8L2;EPS8R2;PP13181;Epidermal growth factor receptor kinase substrate 8-like protein 2;EPS8-like protein 2;Epidermal growth factor receptor pathway substrate 8-related protein 2;EPS8-related protein 2

Observed Band(KD)：81kD

Background： This gene encodes a member of the EPS8 gene family. The encoded protein, like other members of the family, is thought to link growth factor stimulation to actin organization, generating functional redundancy in the pathways that regulate actin cytoskeletal remodeling. [provided by RefSeq, Dec 2008],

Function：function:Stimulates guanine exchange activity of SOS1. May play a role in membrane ruffling and remodeling of the actin cytoskeleton.,similarity:Belongs to the EPS8 family.,similarity:Contains 1 PID domain.,similarity:Contains 1 SH3 domain.,subunit:Interacts with ABI1. Part of a complex that contains SOS1, ABI1 and EPS8L2. Associates with F-actin.,tissue specificity:Detected in fibroblasts and placenta.,

Subcellular Location：Cytoplasm . Cell projection, stereocilium . Localizes at the tips of the stereocilia of the inner and outer hair cells. .

Expression：Detected in fibroblasts and placenta.