Target：Epiregulin
Fields：MAPK signaling pathway;ErbB signaling pathway;PI3K-Akt signaling pathway;Colorectal cancer
Gene Name：EREG
Protein Name：Proepiregulin [Cleaved into: Epiregulin (EPR)]
Human Gene Id：2069
Human Swiss Prot No：O14944
Mouse Gene Id：13874
Mouse Swiss Prot No：Q61521
Immunogen：Synthetic peptide from human protein at AA range: 71-120
Specificity：The antibody detects endogenous Epiregulin
Formulation：Liquid in PBS containing 50% glycerol, 0.5% BSA and 0.02% sodium azide.
Source：Polyclonal, Rabbit,IgG
Dilution：IHC 1:50-200, ELISA 1:10000-20000. IF 1:50-200
Purification：The antibody was affinity-purified from rabbit antiserum by affinity-chromatography using epitope-specific immunogen.
Concentration：1 mg/ml
Storage Stability：-15°C to -25°C/1 year(Do not lower than -25°C)
Other Name：Proepiregulin [Cleaved into: Epiregulin (EPR)]
Background： This gene encodes a secreted peptide hormone and member of the epidermal growth factor (EGF) family of proteins. The encoded protein is a ligand of the epidermal growth factor receptor (EGFR) and the structurally related erb-b2 receptor tyrosine kinase 4 (ERBB4). The encoded protein may be involved in a wide range of biological processes including inflammation, wound healing, oocyte maturation, and cell proliferation. Additionally, the encoded protein may promote the progression of cancers of various human tissues. [provided by RefSeq, Jul 2015],
Function：function:May be a mediator of localized cell proliferation. As a mitogen it may stimulate cell proliferation and/or angiogenesis.,similarity:Contains 1 EGF-like domain.,tissue specificity:In normal adults, expressed predominantly in the placenta and peripheral blood leukocytes. High levels were detected in carcinomas of the bladder, lung, kidney and colon.,
Subcellular Location：[Epiregulin]: Secreted, extracellular space .; [Proepiregulin]: Cell membrane ; Single-pass type I membrane protein .
Expression：In normal adults, expressed predominantly in the placenta and peripheral blood leukocytes. High levels were detected in carcinomas of the bladder, lung, kidney and colon.
