Target：GHRH-R

Fields：Neuroactive ligand-receptor interaction;Growth hormone synthesis, secretion and action

Gene Name：GHRHR

Protein Name：Growth hormone-releasing hormone receptor

Human Gene Id：2692

Human Swiss Prot No：Q02643

Mouse Gene Id：14602

Mouse Swiss Prot No：P32082

Rat Gene Id：25321

Rat Swiss Prot No：Q02644

Immunogen：The antiserum was produced against synthesized peptide derived from human GHRHR. AA range:351-400

Specificity：GHRH-R Polyclonal Antibody detects endogenous levels of GHRH-R protein.

Formulation：Liquid in PBS containing 50% glycerol, 0.5% BSA and 0.02% sodium azide.

Source：Polyclonal, Rabbit,IgG

Dilution：WB 1:500 - 1:2000. IF 1:200 - 1:1000. ELISA: 1:20000. Not yet tested in other applications.

Purification：The antibody was affinity-purified from rabbit antiserum by affinity-chromatography using epitope-specific immunogen.

Concentration：1 mg/ml

Storage Stability：-15°C to -25°C/1 year(Do not lower than -25°C)

Other Name：GHRHR;Growth hormone-releasing hormone receptor;GHRH receptor;Growth hormone-releasing factor receptor;GRF receptor;GRFR

Observed Band(KD)：47kD

Background： This gene encodes a receptor for growth hormone-releasing hormone. Binding of this hormone to the receptor leads to synthesis and release of growth hormone. Mutations in this gene have been associated with isolated growth hormone deficiency (IGHD), also known as Dwarfism of Sindh, a disorder characterized by short stature. [provided by RefSeq, Jun 2010],

Function：disease:Defects in GHRHR are a cause of isolated growth hormone deficiency type IB (IGHD IB) [MIM:262400]; also known as pituitary dwarfism I. IGHD IB is an autosomal recessive deficiency of GH which cause short stature.,function:Receptor for GRF, coupled to G proteins which activate adenylyl cyclase. Stimulates somatotroph cell growth, growth hormone gene transcription and growth hormone secretion.,similarity:Belongs to the G-protein coupled receptor 2 family.,tissue specificity:Pituitary gland.,

Subcellular Location：Cell membrane; Multi-pass membrane protein.

Expression：Pituitary gland.