Target：GGH
Fields：Folate biosynthesis;Biosynthesis of cofactors;Antifolate resistance
Gene Name：GGH
Protein Name：Gamma-glutamyl hydrolase
Human Gene Id：8836
Human Swiss Prot No：Q92820
Mouse Swiss Prot No：Q9Z0L8
Immunogen：The antiserum was produced against synthesized peptide derived from human GGH. AA range:251-300
Specificity：GGH Polyclonal Antibody detects endogenous levels of GGH protein.
Formulation：Liquid in PBS containing 50% glycerol, 0.5% BSA and 0.02% sodium azide.
Source：Polyclonal, Rabbit,IgG
Dilution：WB 1:500 - 1:2000. IHC 1:100 - 1:300. ELISA: 1:10000.. IF 1:50-200
Purification：The antibody was affinity-purified from rabbit antiserum by affinity-chromatography using epitope-specific immunogen.
Concentration：1 mg/ml
Storage Stability：-15°C to -25°C/1 year(Do not lower than -25°C)
Other Name：GGH;Gamma-glutamyl hydrolase;Conjugase;GH;Gamma-Glu-X carboxypeptidase
Observed Band(KD)：36kD
Background： This gene catalyzes the hydrolysis of folylpoly-gamma-glutamates and antifolylpoly-gamma-glutamates by the removal of gamma-linked polyglutamates and glutamate. [provided by RefSeq, Jul 2008],
Function：catalytic activity:Hydrolysis of a gamma-glutamyl bond.,function:Hydrolyzes the polyglutamate sidechains of pteroylpolyglutamates. Progressively removes gamma-glutamyl residues from pteroylpoly-gamma-glutamate to yield pteroyl-alpha-glutamate (folic acid) and free glutamate. May play an important role in the bioavailability of dietary pteroylpolyglutamates and in the metabolism of pteroylpolyglutamates and antifolates.,similarity:Belongs to the peptidase C26 family.,similarity:Contains 1 gamma-glutamyl hydrolase domain.,subcellular location:While its intracellular location is primarily the lysosome, most of the enzyme activity is secreted. Identified by mass spectrometry in melanosome fractions from stage I to stage IV.,
Subcellular Location：Secreted, extracellular space . Lysosome . Melanosome . While its intracellular location is primarily the lysosome, most of the enzyme activity is secreted. Identified by mass spectrometry in melanosome fractions from stage I to stage IV. .
Expression： Skin,
