Target：GFRα-4

Gene Name：GFRA4

Protein Name：GDNF family receptor alpha-4

Human Gene Id：64096

Human Swiss Prot No：Q9GZZ7

Mouse Swiss Prot No：Q9JJT2

Immunogen：The antiserum was produced against synthesized peptide derived from human GFRA4. AA range:141-190

Specificity：GFRα-4 Polyclonal Antibody detects endogenous levels of GFRα-4 protein.

Formulation：Liquid in PBS containing 50% glycerol, 0.5% BSA and 0.02% sodium azide.

Source：Polyclonal, Rabbit,IgG

Dilution：WB 1:500 - 1:2000. ELISA: 1:10000. Not yet tested in other applications.

Purification：The antibody was affinity-purified from rabbit antiserum by affinity-chromatography using epitope-specific immunogen.

Concentration：1 mg/ml

Storage Stability：-15°C to -25°C/1 year(Do not lower than -25°C)

Other Name：GFRA4;GDNF family receptor alpha-4;GDNF receptor alpha-4;GDNFR-alpha-4;GFR-alpha-4;Persephin receptor

Observed Band(KD)：30kD

Background： The protein encoded by this gene is a member of the GDNF receptor family. It is a glycosylphosphatidylinositol(GPI)-linked cell surface receptor for persephin, and mediates activation of the RET tyrosine kinase receptor. This gene is a candidate gene for RET-associated diseases. Alternatively spliced transcript variants encoding different isoforms have been described for this gene. [provided by RefSeq, Jul 2008],

Function：alternative products:Additional isoforms seem to exist,function:Receptor for persephin. Mediates the GDNF-induced autophosphorylation and activation of the RET receptor. May be important in C-cell development and, in the postnatal development of the adrenal medulla.,similarity:Belongs to the GDNFR family.,tissue specificity:Predominantly expressed in the adult thyroid gland. Low levels also found in fetal adrenal and thyroid glands.,

Subcellular Location：[Isoform GFRalpha4a]: Cell membrane; Lipid-anchor, GPI-anchor.; [Isoform GFRalpha4b]: Cell membrane; Lipid-anchor, GPI-anchor.; [Isoform GFRalpha4c]: Secreted.

Expression：Predominantly expressed in the adult thyroid gland. Low levels also found in fetal adrenal and thyroid glands.