Target：GFRP
Gene Name：GCHFR
Protein Name：GTP cyclohydrolase 1 feedback regulatory protein
Human Gene Id：2644
Human Swiss Prot No：P30047
Mouse Swiss Prot No：P99025
Rat Gene Id：171128
Rat Swiss Prot No：P70552
Immunogen：The antiserum was produced against synthesized peptide derived from human GCHFR. AA range:31-80
Specificity：GFRP Polyclonal Antibody detects endogenous levels of GFRP protein.
Formulation：Liquid in PBS containing 50% glycerol, 0.5% BSA and 0.02% sodium azide.
Source：Polyclonal, Rabbit,IgG
Dilution：IHC 1:100 - 1:300. ELISA: 1:10000.. IF 1:50-200
Purification：The antibody was affinity-purified from rabbit antiserum by affinity-chromatography using epitope-specific immunogen.
Concentration：1 mg/ml
Storage Stability：-15°C to -25°C/1 year(Do not lower than -25°C)
Other Name：GCHFR;GFRP;GTP cyclohydrolase 1 feedback regulatory protein;GFRP;GTP cyclohydrolase I feedback regulatory protein;p35
Molecular Weight(Da)：10kD
Background： GTP cyclohydrolase I feedback regulatory protein binds to and mediates tetrahydrobiopterin inhibition of GTP cyclohydrolase I. The regulatory protein, GCHFR, consists of a homodimer. It is postulated that GCHFR may play a role in regulating phenylalanine metabolism in the liver and in the production of biogenic amine neurotransmitters and nitric oxide. [provided by RefSeq, Jul 2008],
Function：function:Mediates tetrahydrobiopterin inhibition of GTP cyclohydrolase 1. This inhibition is reversed by L-phenylalanine.,similarity:Belongs to the GFRP family.,subunit:Homopentamer. Forms a complex with GCH1 where a GCH1 homodecamer is sandwiched by two GFRP homopentamers (By similarity). Interacts with GCH1.,tissue specificity:In epidermis, expressed predominantly in basal undifferentiated keratinocytes and in some but not all melanocytes (at protein level).,
Subcellular Location：Nucleus . Nucleus membrane . Cytoplasm, cytosol .
Expression：In epidermis, expressed predominantly in basal undifferentiated keratinocytes and in some but not all melanocytes (at protein level).
