Target：Endoglycan

Gene Name：PODXL2

Protein Name：Podocalyxin-like protein 2

Human Gene Id：50512

Human Swiss Prot No：Q9NZ53

Mouse Swiss Prot No：Q8CAE9

Immunogen：Synthesized peptide derived from the Internal region of human Endoglycan.

Specificity：Endoglycan Polyclonal Antibody detects endogenous levels of Endoglycan protein.

Formulation：Liquid in PBS containing 50% glycerol, 0.5% BSA and 0.02% sodium azide.

Source：Polyclonal, Rabbit,IgG

Dilution：WB 1:500 - 1:2000. ELISA: 1:10000. Not yet tested in other applications.

Purification：The antibody was affinity-purified from rabbit antiserum by affinity-chromatography using epitope-specific immunogen.

Concentration：1 mg/ml

Storage Stability：-15°C to -25°C/1 year(Do not lower than -25°C)

Other Name：PODXL2;Podocalyxin-like protein 2;Endoglycan

Observed Band(KD)：65kD

Background： This gene is a member of the CD34 family of cell surface transmembrane proteins, which are characterized by an N-terminal extracellular mucin domain, globular and stalk domains, a single pass transmembrane region, and a charged cytoplasmic tail. The encoded protein is a ligand for vascular selectins. [provided by RefSeq, Oct 2012],

Function：PTM:Glycosylated; contains chondroitin sulfate. Displays sialylated O-linked oligosaccharides.,PTM:Sulfation and sialylated O-linked oligosaccharides are necessary for SELL/L-selectin binding.,similarity:Belongs to the podocalyxin family.,subunit:Homodimer; disulfide-linked. Binds to SELL/L-selectin.,tissue specificity:Highly expressed in brain. Moderately expressed in pancreas, kidney and lymphoid node. Weakly expressed in liver. Detected in both endothelial cells and CD34+ bone marrow cells.,

Subcellular Location：Membrane ; Single-pass type I membrane protein .

Expression：Expressed in T-cells, B-cells and monocytes. Expression is higher on memory and germinal center cells than on naive B-cells (at protein level). Highly expressed in brain. Moderately expressed in pancreas, kidney and lymphoid node. Weakly expressed in liver. Detected in both endothelial cells and CD34+ bone marrow cells.