Target：Endo G-L1

Gene Name：EXOG

Protein Name：Nuclease EXOG mitochondrial

Human Gene Id：9941

Human Swiss Prot No：Q9Y2C4

Mouse Swiss Prot No：Q8C163

Immunogen：The antiserum was produced against synthesized peptide derived from human ENDOGL1. AA range:171-220

Specificity：Endo G-L1 Polyclonal Antibody detects endogenous levels of Endo G-L1 protein.

Formulation：Liquid in PBS containing 50% glycerol, 0.5% BSA and 0.02% sodium azide.

Source：Polyclonal, Rabbit,IgG

Dilution：WB 1:500 - 1:2000. ELISA: 1:40000. Not yet tested in other applications.

Purification：The antibody was affinity-purified from rabbit antiserum by affinity-chromatography using epitope-specific immunogen.

Concentration：1 mg/ml

Storage Stability：-15°C to -25°C/1 year(Do not lower than -25°C)

Other Name：EXOG;ENDOGL1;ENDOGL2;ENGL;Nuclease EXOG; mitochondrial;Endonuclease G-like 1;Endo G-like 1

Observed Band(KD)：41kD

Background： This gene encodes an endo/exonuclease with 5'-3' exonuclease activity. The encoded enzyme catalyzes the hydrolysis of ester linkages at the 5' end of a nucleic acid chain. This enzyme is localized to the mitochondria and may play a role in programmed cell death. Alternatively spliced transcript variants have been described. A pseudogene exists on chromosome 18. [provided by RefSeq, Feb 2009],

Function：cofactor:Divalent metal cations.,function:Endo/exonuclease with nicking activity towards supercoiled DNA, a preference for single stranded DNA and 5'-3' exonuclease activity.,miscellaneous:The active site contains 1 hydrated divalent metal cation that has only 1 direct interaction with the protein; all other interactions are via water molecules.,similarity:Belongs to the DNA/RNA non-specific endonuclease family.,subunit:Homodimer.,tissue specificity:Ubiquitous.,

Subcellular Location：Mitochondrion inner membrane .

Expression：Ubiquitous.