Target：Elmo1

Fields：Chemokine signaling pathway;Bacterial invasion of epithelial cells;Shigellosis;Salmonella infection;Yersinia infection

Gene Name：ELMO1

Protein Name：Engulfment and cell motility protein 1

Human Gene Id：9844

Human Swiss Prot No：Q92556

Mouse Gene Id：140580

Mouse Swiss Prot No：Q8BPU7

Immunogen：The antiserum was produced against synthesized peptide derived from human Elmo1. AA range:22-71

Specificity：Elmo1 Polyclonal Antibody detects endogenous levels of Elmo1 protein.

Formulation：Liquid in PBS containing 50% glycerol, 0.5% BSA and 0.02% sodium azide.

Source：Polyclonal, Rabbit,IgG

Dilution：WB 1:500 - 1:2000. ELISA: 1:20000. Not yet tested in other applications.

Purification：The antibody was affinity-purified from rabbit antiserum by affinity-chromatography using epitope-specific immunogen.

Concentration：1 mg/ml

Storage Stability：-15°C to -25°C/1 year(Do not lower than -25°C)

Other Name：ELMO1;KIAA0281;Engulfment and cell motility protein 1;Protein ced-12 homolog

Observed Band(KD)：83kD

Background： This gene encodes a member of the engulfment and cell motility protein family. These proteins interact with dedicator of cytokinesis proteins to promote phagocytosis and cell migration. Increased expression of this gene and dedicator of cytokinesis 1 may promote glioma cell invasion, and single nucleotide polymorphisms in this gene may be associated with diabetic nephropathy. Alternative splicing results in multiple transcript variants. [provided by RefSeq, Aug 2013],

Function：function:Involved in cytoskeletal rearrangements required for phagocytosis of apoptotic cells and cell motility. Acts in assocation with DOCK1 and CRK. Was initially proposed to be required in complex with DOCK1 to activate Rac Rho small GTPases. May enhance the guanine nucleotide exchange factor (GEF) activity of DOCK1.,PTM:Phosphorylated by HCK.,similarity:Contains 1 ELMO domain.,similarity:Contains 1 PH domain.,subcellular location:Translocation to plasma membrane seems to be mediated by DOCK1 and CRK.,subunit:Interacts with BAI1 (By similarity). Interacts directly with the SH3-domain of DOCK1 via its SH3-binding site. Part of a complex with DOCK1 and RAC1. Part of a complex with DOCK1 and CRK isoform CRK-II. Interacts with PLEKHG6.,tissue specificity:Widely expressed, with a higher expression in the spleen and placenta.,

Subcellular Location：Cytoplasm. Cell membrane. Translocation to plasma membrane seems to be mediated by DOCK1 and CRK.

Expression：Widely expressed, with a higher expression in the spleen and placenta.