Target：ASF1B
Gene Name：ASF1B
Protein Name：Histone chaperone ASF1B
Human Gene Id：55723
Human Swiss Prot No：Q9NVP2
Mouse Gene Id：66929
Mouse Swiss Prot No：Q9DAP7
Immunogen：The antiserum was produced against synthesized peptide derived from human ASF1B. AA range:101-150
Specificity：ASF1B Polyclonal Antibody detects endogenous levels of ASF1B protein.
Formulation：Liquid in PBS containing 50% glycerol, 0.5% BSA and 0.02% sodium azide.
Source：Polyclonal, Rabbit,IgG
Dilution：WB 1:500 - 1:2000. IHC 1:100 - 1:300. ELISA: 1:5000.. IF 1:50-200
Purification：The antibody was affinity-purified from rabbit antiserum by affinity-chromatography using epitope-specific immunogen.
Concentration：1 mg/ml
Storage Stability：-15°C to -25°C/1 year(Do not lower than -25°C)
Other Name：ASF1B;Histone chaperone ASF1B;Anti-silencing function protein 1 homolog B;hAsf1;hAsf1b;CCG1-interacting factor A-II;CIA-II;hCIA-II
Observed Band(KD)：26kD
Background： This gene encodes a member of the H3/H4 family of histone chaperone proteins and is similar to the anti-silencing function-1 gene in yeast. The encoded protein is the substrate of the tousled-like kinase family of cell cycle-regulated kinases, and may play a key role in modulating the nucleosome structure of chromatin by ensuring a constant supply of histones at sites of nucleosome assembly. [provided by RefSeq, Jul 2008],
Function：function:Histone chaperone that facilitates histone deposition and histone exchange and removal during nucleosome assembly and disassembly. Cooperates with chromatin assembly factor 1 (CAF-1) to promote replication-dependent chromatin assembly. Does not participate in replication-independent nucleosome deposition which is mediated by ASF1A and HIRA. Required for spermatogenesis.,PTM:Phosphorylated by TLK1 and TLK2.,similarity:Belongs to the ASF1 family.,subunit:Interacts with histone H3 (including both histone H3.1 and H3.3) and histone H4. Interacts with the CHAF1A, CHAF1B and RBBP4 subunits of the CAF-1 complex. Interacts with HAT1, NASP, TAF1, TLK1 and TLK2.,tissue specificity:Highly expressed in testis and at lower levels in colon, small intestine and thymus.,
Subcellular Location：Nucleus .
Expression：Highly expressed in testis and at lower levels in colon, small intestine and thymus.
