Target：ASAH3L

Fields：Sphingolipid metabolism;Metabolic pathways;Sphingolipid signaling pathway

Gene Name：ACER2

Protein Name：Alkaline ceramidase 2

Human Gene Id：340485

Human Swiss Prot No：Q5QJU3

Mouse Gene Id：230379

Mouse Swiss Prot No：Q8VD53

Immunogen：Synthesized peptide derived from ASAH3L . at AA range: 50-130

Specificity：ASAH3L Polyclonal Antibody detects endogenous levels of ASAH3L protein.

Formulation：Liquid in PBS containing 50% glycerol, 0.5% BSA and 0.02% sodium azide.

Source：Polyclonal, Rabbit,IgG

Dilution：WB 1:500 - 1:2000. IHC: 1:100-1:300. ELISA: 1:10000.. IF 1:50-200

Purification：The antibody was affinity-purified from rabbit antiserum by affinity-chromatography using epitope-specific immunogen.

Concentration：1 mg/ml

Storage Stability：-15°C to -25°C/1 year(Do not lower than -25°C)

Other Name：ACER2;ASAH3L;PP11646;Alkaline ceramidase 2;AlkCDase 2;Alkaline CDase 2;haCER2;Acylsphingosine deacylase 3-like;N-acylsphingosine amidohydrolase 3-like

Observed Band(KD)：33kD

Background： The sphingolipid metabolite sphingosine-1-phosphate promotes cell proliferation and survival, whereas its precursor, sphingosine, has the opposite effect. The ceramidase ACER2 hydrolyzes very long chain ceramides to generate sphingosine (Xu et al., 2006 [PubMed 16940153]).[supplied by OMIM, Jul 2010],

Function：catalytic activity:N-acylsphingosine + H(2)O = a carboxylate + sphingosine.,function:Hydrolyzes the sphingolipid ceramide into sphingosine and free fatty acid.,similarity:Belongs to the alkaline ceramidase family.,

Subcellular Location：Golgi apparatus membrane ; Multi-pass membrane protein .

Expression：Highly expressed in placenta.