Target：AR-β3

Fields：Calcium signaling pathway;cGMP-PKG signaling pathway;Neuroactive ligand-receptor interaction;Thermogenesis;Regulation of lipolysis in adipocytes;Renin secretion;Salivary secretion;Chemical carcinogenesis - receptor activation

Gene Name：ADRB3

Protein Name：Beta-3 adrenergic receptor

Human Gene Id：155

Human Swiss Prot No：P13945

Mouse Gene Id：11556

Mouse Swiss Prot No：P25962

Rat Gene Id：25645

Rat Swiss Prot No：P26255

Immunogen：The antiserum was produced against synthesized peptide derived from human ADRB3. AA range:250-299

Specificity：AR-β3 Polyclonal Antibody detects endogenous levels of AR-β3 protein.

Formulation：Liquid in PBS containing 50% glycerol, 0.5% BSA and 0.02% sodium azide.

Source：Polyclonal, Rabbit,IgG

Dilution：WB 1:500-2000 IF 1:100-300 ELISA 1:5000-20000 Not yet tested in other applications.

Purification：The antibody was affinity-purified from rabbit antiserum by affinity-chromatography using epitope-specific immunogen.

Concentration：1 mg/ml

Storage Stability：-15°C to -25°C/1 year(Do not lower than -25°C)

Other Name：ADRB3;ADRB3R;B3AR;Beta-3 adrenergic receptor;Beta-3 adrenoreceptor;Beta-3 adrenoceptor

Observed Band(KD)：36kD

Background： The protein encoded by this gene belongs to the family of beta adrenergic receptors, which mediate catecholamine-induced activation of adenylate cyclase through the action of G proteins. This receptor is located mainly in the adipose tissue and is involved in the regulation of lipolysis and thermogenesis. [provided by RefSeq, Feb 2009],

Function：function:Beta-adrenergic receptors mediate the catecholamine-induced activation of adenylate cyclase through the action of G proteins. Beta-3 is involved in the regulation of lipolysis and thermogenesis.,polymorphism:The variant Arg-64 seems to be associated with weight gain (obesity) and to is also associated with susceptibility to non-insulin-dependent diabetes mellitus (NIDDM).,similarity:Belongs to the G-protein coupled receptor 1 family.,tissue specificity:Expressed mainly in adipose tissues.,

Subcellular Location：Cell membrane; Multi-pass membrane protein.

Expression：Expressed mainly in adipose tissues.