Target：AR-α1B

Fields：Calcium signaling pathway;cGMP-PKG signaling pathway;Neuroactive ligand-receptor interaction;Adrenergic signaling in cardiomyocytes;Vascular smooth muscle contraction;Salivary secretion

Gene Name：ADRA1B

Protein Name：Alpha-1B adrenergic receptor

Human Gene Id：147

Human Swiss Prot No：P35368

Mouse Swiss Prot No：P97717

Rat Swiss Prot No：P15823

Immunogen：The antiserum was produced against synthesized peptide derived from human ADRA1B. AA range:431-480

Specificity：AR-α1B Polyclonal Antibody detects endogenous levels of AR-α1B protein.

Formulation：Liquid in PBS containing 50% glycerol, 0.5% BSA and 0.02% sodium azide.

Source：Polyclonal, Rabbit,IgG

Dilution：WB 1:500 - 1:2000. IF 1:200 - 1:1000. ELISA: 1:20000. Not yet tested in other applications.

Purification：The antibody was affinity-purified from rabbit antiserum by affinity-chromatography using epitope-specific immunogen.

Concentration：1 mg/ml

Storage Stability：-15°C to -25°C/1 year(Do not lower than -25°C)

Other Name：ADRA1B;Alpha-1B adrenergic receptor;Alpha-1B adrenoreceptor;Alpha-1B adrenoceptor

Observed Band(KD)：60kD

Background： Alpha-1-adrenergic receptors (alpha-1-ARs) are members of the G protein-coupled receptor superfamily. They activate mitogenic responses and regulate growth and proliferation of many cells. There are 3 alpha-1-AR subtypes: alpha-1A, -1B and -1D, all of which signal through the Gq/11 family of G-proteins and different subtypes show different patterns of activation. This gene encodes alpha-1B-adrenergic receptor, which induces neoplastic transformation when transfected into NIH 3T3 fibroblasts and other cell lines. Thus, this normal cellular gene is identified as a protooncogene. This gene comprises 2 exons and a single large intron of at least 20 kb that interrupts the coding region. [provided by RefSeq, Jul 2008],

Function：function:This alpha-adrenergic receptor mediates its action by association with G proteins that activate a phosphatidylinositol-calcium second messenger system.,similarity:Belongs to the G-protein coupled receptor 1 family.,

Subcellular Location：Nucleus membrane; Multi-pass membrane protein. Cell membrane ; Multi-pass membrane protein . Cytoplasm . Membrane, caveola . Location at the nuclear membrane facilitates heterooligomerization and regulates ERK-mediated signaling in cardiac myocytes. signaling in cardiac myocytes. Colocalizes with GNAQ, PLCB1 as well as LAP2 at the nuclear membrane of cardiac myocytes.

Expression： Brain,