Target：ARPP-21

Gene Name：ARPP21

Protein Name：cAMP-regulated phosphoprotein 21

Human Gene Id：10777

Human Swiss Prot No：Q9UBL0

Mouse Gene Id：74100

Mouse Swiss Prot No：Q9DCB4

Immunogen：The antiserum was produced against synthesized peptide derived from human ARPP21. AA range:211-260

Specificity：ARPP-21 Polyclonal Antibody detects endogenous levels of ARPP-21 protein.

Formulation：Liquid in PBS containing 50% glycerol, 0.5% BSA and 0.02% sodium azide.

Source：Polyclonal, Rabbit,IgG

Dilution：WB 1:500 - 1:2000. IHC 1:100 - 1:300. ELISA: 1:5000.. IF 1:50-200

Purification：The antibody was affinity-purified from rabbit antiserum by affinity-chromatography using epitope-specific immunogen.

Concentration：1 mg/ml

Storage Stability：-15°C to -25°C/1 year(Do not lower than -25°C)

Other Name：ARPP21;TARPP;cAMP-regulated phosphoprotein 21;ARPP-21;Thymocyte cAMP-regulated phosphoprotein

Observed Band(KD)：80kD

Background： This gene encodes a cAMP-regulated phosphoprotein. The encoded protein is enriched in the caudate nucleus and cerebellar cortex. A similar protein in mouse may be involved in regulating the effects of dopamine in the basal ganglia. Alternate splicing results in multiple transcript variants. [provided by RefSeq, Jun 2012],

Function：function:Isoform 2 may act as a competitive inhibitor of calmodulin-dependent enzymes such as calcineurin in neurons.,PTM:Isoform 1 is methylated by CARM1 in immature thymocytes.,PTM:Phosphorylation at Ser-56 favors interaction with CALM1.,similarity:Contains 1 R3H domain.,subunit:Interacts with CALM1.,tissue specificity:Isoform 2 is expressed in brain. Isoform 1 is present in immature thymocytes (at protein level).,

Subcellular Location：Cytoplasm .

Expression：Isoform 2 is expressed in brain. Isoform 1 is present in immature thymocytes (at protein level).