Target：ATF-3

Gene Name：ATF3

Protein Name：Cyclic AMP-dependent transcription factor ATF-3

Human Gene Id：467

Human Swiss Prot No：P18847

Mouse Gene Id：11910

Mouse Swiss Prot No：Q60765

Rat Gene Id：25389

Rat Swiss Prot No：P29596

Immunogen：The antiserum was produced against synthesized peptide derived from human ATF3. AA range:131-180

Specificity：ATF-3 Polyclonal Antibody detects endogenous levels of ATF-3 protein.

Formulation：Liquid in PBS containing 50% glycerol, 0.5% BSA and 0.02% sodium azide.

Source：Polyclonal, Rabbit,IgG

Dilution：WB 1:500-2000;IHC 1:100-500;IF ICC 1:100-500;ELISA 1:5000-20000

Purification：The antibody was affinity-purified from rabbit antiserum by affinity-chromatography using epitope-specific immunogen.

Concentration：1 mg/ml

Storage Stability：-15°C to -25°C/1 year(Do not lower than -25°C)

Other Name：ATF3;Cyclic AMP-dependent transcription factor ATF-3;cAMP-dependent transcription factor ATF-3;Activating transcription factor 3

Observed Band(KD)：21kD

Background：activating transcription factor 3(ATF3) Homo sapiens This gene encodes a member of the mammalian activation transcription factor/cAMP responsive element-binding (CREB) protein family of transcription factors. This gene is induced by a variety of signals, including many of those encountered by cancer cells, and is involved in the complex process of cellular stress response. Multiple transcript variants encoding different isoforms have been found for this gene. It is possible that alternative splicing of this gene may be physiologically important in the regulation of target genes. [provided by RefSeq, Apr 2011],

Function：function:This protein binds the cAMP response element (CRE) (consensus: 5'-GTGACGT[AC][AG]-3'), a sequence present in many viral and cellular promoters. Represses transcription from promoters with ATF sites. It may repress transcription by stabilizing the binding of inhibitory cofactors at the promoter. Isoform 2 activates transcription presumably by sequestering inhibitory cofactors away from the promoters.,similarity:Belongs to the bZIP family.,similarity:Belongs to the bZIP family. ATF subfamily.,similarity:Contains 1 bZIP domain.,subunit:Binds DNA as a homodimer or a heterodimer.,

Subcellular Location：Nucleus .

Expression： Amygdala,Brain,Cerebellum,Muscle,