Target：EDEM2

Fields：Protein processing in endoplasmic reticulum

Gene Name：EDEM2

Protein Name：ER degradation-enhancing alpha-mannosidase-like 2

Human Gene Id：55741

Human Swiss Prot No：Q9BV94

Immunogen：Synthesized peptide derived from the C-terminal region of human EDEM2.

Specificity：EDEM2 Polyclonal Antibody detects endogenous levels of EDEM2 protein.

Formulation：Liquid in PBS containing 50% glycerol, 0.5% BSA and 0.02% sodium azide.

Source：Polyclonal, Rabbit,IgG

Dilution：IHC 1:100 - 1:300. ELISA: 1:10000.. IF 1:50-200

Purification：The antibody was affinity-purified from rabbit antiserum by affinity-chromatography using epitope-specific immunogen.

Concentration：1 mg/ml

Storage Stability：-15°C to -25°C/1 year(Do not lower than -25°C)

Other Name：EDEM2;C20orf31;C20orf49;ER degradation-enhancing alpha-mannosidase-like 2

Molecular Weight(Da)：65kD

Background： In the endoplasmic reticulum (ER), misfolded proteins are retrotranslocated to the cytosol and degraded by the proteasome in a process known as ER-associated degradation (ERAD). EDEM2 belongs to a family of proteins involved in ERAD of glycoproteins (Mast et al., 2005 [PubMed 15537790]).[supplied by OMIM, Mar 2008],

Function：similarity:Belongs to the glycosyl hydrolase 47 family.,

Subcellular Location：Endoplasmic reticulum lumen .

Expression：Expressed ubiquitously in all tissues tested with slightly higher levels detected in small intestine and peripheral blood leukocytes and weakest levels in brain and skeletal muscle.