Target：DSCR 1

Fields：Thyroid hormone signaling pathway;Oxytocin signaling pathway;Kaposi sarcoma-associated herpesvirus infection

Gene Name：RCAN1

Protein Name：Calcipressin-1

Human Gene Id：1827

Human Swiss Prot No：P53805

Mouse Gene Id：54720

Mouse Swiss Prot No：Q9JHG6

Rat Gene Id：266766

Rat Swiss Prot No：Q6IN33

Immunogen：The antiserum was produced against synthesized peptide derived from human RCAN1. AA range:201-250

Specificity：DSCR 1 Polyclonal Antibody detects endogenous levels of DSCR 1 protein.

Formulation：Liquid in PBS containing 50% glycerol, 0.5% BSA and 0.02% sodium azide.

Source：Polyclonal, Rabbit,IgG

Dilution：WB 1:500 - 1:2000. ELISA: 1:10000. Not yet tested in other applications.

Purification：The antibody was affinity-purified from rabbit antiserum by affinity-chromatography using epitope-specific immunogen.

Concentration：1 mg/ml

Storage Stability：-15°C to -25°C/1 year(Do not lower than -25°C)

Other Name：RCAN1;ADAPT78;CSP1;DSC1;DSCR1;Calcipressin-1;Adapt78;Down syndrome critical region protein 1;Myocyte-enriched calcineurin-interacting protein 1;MCIP1;Regulator of calcineurin 1

Observed Band(KD)：22kD

Background： The protein encoded by this gene interacts with calcineurin A and inhibits calcineurin-dependent signaling pathways, possibly affecting central nervous system development. This gene is located in the minimal candidate region for the Down syndrome phenotype, and is overexpressed in the brain of Down syndrome fetuses. Chronic overexpression of this gene may lead to neurofibrillary tangles such as those associated with Alzheimer disease. Alternative splicing results in multiple transcript variants. [provided by RefSeq, Nov 2013],

Function：function:Inhibits calcineurin-dependent transcriptional responses by binding to the catalytic domain of calcineurin A. Could play a role during central nervous system development.,induction:By calcium.,similarity:Belongs to the RCAN family.,tissue specificity:Highly expressed heart, brain and skeletal muscle. Also expressed in all other tissues.,

Subcellular Location：intracellular,nucleus,cytoplasm,

Expression：Highly expressed heart, brain and skeletal muscle. Also expressed in all other tissues.