Target：APC5

Fields：Cell cycle;Oocyte meiosis;Ubiquitin mediated proteolysis;IL-17 signaling pathway;Progesterone-mediated oocyte maturation;Human T-cell leukemia virus 1 infection

Gene Name：ANAPC5

Protein Name：Anaphase-promoting complex subunit 5

Human Gene Id：51433

Human Swiss Prot No：Q9UJX4

Mouse Swiss Prot No：Q8BTZ4

Immunogen：The antiserum was produced against synthesized peptide derived from human ANAPC5. AA range:151-200

Specificity：APC5 Polyclonal Antibody detects endogenous levels of APC5 protein.

Formulation：Liquid in PBS containing 50% glycerol, 0.5% BSA and 0.02% sodium azide.

Source：Polyclonal, Rabbit,IgG

Dilution：WB 1:500 - 1:2000. ELISA: 1:5000. Not yet tested in other applications.

Purification：The antibody was affinity-purified from rabbit antiserum by affinity-chromatography using epitope-specific immunogen.

Concentration：1 mg/ml

Storage Stability：-15°C to -25°C/1 year(Do not lower than -25°C)

Other Name：ANAPC5;APC5;Anaphase-promoting complex subunit 5;APC5;Cyclosome subunit 5

Observed Band(KD)：85kD

Background： This gene encodes a tetratricopeptide repeat-containing component of the anaphase promoting complex/cyclosome (APC/C), a large E3 ubiquitin ligase that controls cell cycle progression by targeting a number of cell cycle regulators such as B-type cyclins for 26S proteasome-mediated degradation through ubiquitination. The encoded protein is required for the proper ubiquitination function of APC/C and for the interaction of APC/C with transcription coactivators. It also interacts with polyA binding protein and represses internal ribosome entry site-mediated translation. Multiple transcript variants encoding different isoforms have been found for this gene. These differences cause translation initiation at a downstream AUG and result in a shorter protein (isoform b), compared to isoform a. [provided by RefSeq, Nov 2008],

Function：function:Component of the anaphase promoting complex/cyclosome (APC/C), a cell cycle-regulated ubiquitin ligase that controls progression through mitosis and the G1 phase of the cell cycle.,pathway:Protein modification; protein ubiquitination.,similarity:Belongs to the APC5 family.,similarity:Contains 4 TPR repeats.,subunit:The APC/C is composed of at least 11 subunits.,

Subcellular Location：Nucleus . Cytoplasm, cytoskeleton, spindle .

Expression： Brain,Cerebellum,Cervix,Epithelium,Lung,Oesophagus,Periodontal liga