Target：DNA pol ε 4

Fields：DNA replication;Base excision repair;Nucleotide excision repair

Gene Name：POLE4

Protein Name：DNA polymerase epsilon subunit 4

Human Gene Id：56655

Human Swiss Prot No：Q9NR33

Mouse Gene Id：66979

Mouse Swiss Prot No：Q9CQ36

Immunogen：The antiserum was produced against synthesized peptide derived from human POLE4. AA range:61-110

Specificity：DNA pol ε 4 Polyclonal Antibody detects endogenous levels of DNA pol ε 4 protein.

Formulation：Liquid in PBS containing 50% glycerol, 0.5% BSA and 0.02% sodium azide.

Source：Polyclonal, Rabbit,IgG

Dilution：IHC 1:100 - 1:300. ELISA: 1:40000.. IF 1:50-200

Purification：The antibody was affinity-purified from rabbit antiserum by affinity-chromatography using epitope-specific immunogen.

Concentration：1 mg/ml

Storage Stability：-15°C to -25°C/1 year(Do not lower than -25°C)

Other Name：POLE4;DNA polymerase epsilon subunit 4;DNA polymerase II subunit 4;DNA polymerase epsilon subunit p12

Observed Band(KD)：12kD

Background： POLE4 is a histone-fold protein that interacts with other histone-fold proteins to bind DNA in a sequence-independent manner. These histone-fold protein dimers combine within larger enzymatic complexes for DNA transcription, replication, and packaging.[supplied by OMIM, Apr 2004],

Function：catalytic activity:Deoxynucleoside triphosphate + DNA(n) = diphosphate + DNA(n+1).,function:May play a role in allowing polymerase epsilon to carry out its replication and/or repair function.,PTM:Phosphorylated upon DNA damage, probably by ATM or ATR.,subunit:Consists of four subunits: POLE1, POLE2, POLE3 and POLE4. Interacts with POLE3. When bound to POLE3, it can associate with polymerase epsilon p261 and p59 and form a complex.,

Subcellular Location：Nucleus .

Expression： Cervix carcinoma,Skin,