Target：DLL4

Fields：Endocrine resistance;Notch signaling pathway;Th1 and Th2 cell differentiation;Pathways in cancer;Chemical carcinogenesis - receptor activation;Breast cancer

Gene Name：DLL4 UNQ1895/PRO4341

Protein Name：Delta-like protein 4 (Drosophila Delta homolog 4) (Delta4)

Human Gene Id：54567

Human Swiss Prot No：Q9NR61

Mouse Swiss Prot No：Q9JI71

Immunogen：Synthesized peptide derived from part region of human protein

Specificity：DLL4 Polyclonal Antibody detects endogenous levels of protein.

Formulation：Liquid in PBS containing 50% glycerol, and 0.02% sodium azide.

Source：Polyclonal, Rabbit,IgG

Dilution：WB 1:500-2000 ELISA 1:5000-20000

Purification：The antibody was affinity-purified from rabbit antiserum by affinity-chromatography using epitope-specific immunogen.

Concentration：1 mg/ml

Storage Stability：-15°C to -25°C/1 year(Do not lower than -25°C)

Observed Band(KD)：75kD

Background： This gene is a homolog of the Drosophila delta gene. The delta gene family encodes Notch ligands that are characterized by a DSL domain, EGF repeats, and a transmembrane domain. [provided by RefSeq, Jul 2008],

Function：domain:The Delta-Serrate-Lag2 (DSL) domain is required for binding to the Notch receptor.,function:Plays a role in the Notch signaling pathway. Activates Notch-1 and Notch-4.,PTM:Ubiquitinated by MIB (MIB1 or MIB2), leading to its endocytosis and subsequent degradation.,similarity:Contains 1 DSL domain.,similarity:Contains 8 EGF-like domains.,subunit:Binds to Notch-1 and Notch-4.,tissue specificity:Expressed in vascular endothelium.,

Subcellular Location：Cell membrane ; Single-pass type I membrane protein .

Expression：Expressed in vascular endothelium.