Target：DHODH

Fields：Pyrimidine metabolism;Metabolic pathways;Biosynthesis of cofactors

Gene Name：DHODH

Protein Name：Dihydroorotate dehydrogenase

Human Gene Id：1723

Human Swiss Prot No：Q02127

Mouse Swiss Prot No：O35435

Immunogen：The antiserum was produced against synthesized peptide derived from human DHODH. AA range:211-260

Specificity：DHODH Polyclonal Antibody detects endogenous levels of DHODH protein.

Formulation：Liquid in PBS containing 50% glycerol, 0.5% BSA and 0.02% sodium azide.

Source：Polyclonal, Rabbit,IgG

Dilution：WB 1:500 - 1:2000. IHC 1:100 - 1:300. ELISA: 1:40000.. IF 1:50-200

Purification：The antibody was affinity-purified from rabbit antiserum by affinity-chromatography using epitope-specific immunogen.

Concentration：1 mg/ml

Storage Stability：-15°C to -25°C/1 year(Do not lower than -25°C)

Other Name：DHODH;Dihydroorotate dehydrogenase;quinone); mitochondrial;DHOdehase;Dihydroorotate oxidase

Observed Band(KD)：48kD

Background： The protein encoded by this gene catalyzes the fourth enzymatic step, the ubiquinone-mediated oxidation of dihydroorotate to orotate, in de novo pyrimidine biosynthesis. This protein is a mitochondrial protein located on the outer surface of the inner mitochondrial membrane. [provided by RefSeq, Jul 2008],

Function：catalytic activity:(S)-dihydroorotate + O(2) = orotate + H(2)O(2).,cofactor:Binds 1 FAD per subunit.,pathway:Pyrimidine metabolism; UMP biosynthesis via de novo pathway; UMP from HCO(3)(-): step 4/6.,similarity:Belongs to the dihydroorotate dehydrogenase family.,

Subcellular Location：Mitochondrion inner membrane ; Single-pass membrane protein .

Expression： Skin,Testis,