Target：DHA Kinase

Fields：Fructose and mannose metabolism;Glycerolipid metabolism;Metabolic pathways;Carbon metabolism;RIG-I-like receptor signaling pathway

Gene Name：DAK

Protein Name：Bifunctional ATP-dependent dihydroxyacetone kinase/FAD-AMP lyase

Human Gene Id：26007

Human Swiss Prot No：Q3LXA3

Mouse Gene Id：225913

Mouse Swiss Prot No：Q8VC30

Rat Gene Id：361730

Rat Swiss Prot No：Q4KLZ6

Immunogen：The antiserum was produced against synthesized peptide derived from human DAK. AA range:91-140

Specificity：DHA Kinase Polyclonal Antibody detects endogenous levels of DHA Kinase protein.

Formulation：Liquid in PBS containing 50% glycerol, 0.5% BSA and 0.02% sodium azide.

Source：Polyclonal, Rabbit,IgG

Dilution：WB 1:200 - 1:1000. ELISA: 1:20000.. IF 1:20-50

Purification：The antibody was affinity-purified from rabbit antiserum by affinity-chromatography using epitope-specific immunogen.

Concentration：1 mg/ml

Storage Stability：-15°C to -25°C/1 year(Do not lower than -25°C)

Other Name：DAK;Bifunctional ATP-dependent dihydroxyacetone kinase/FAD-AMP lyase;cyclizing

Observed Band(KD)：59kD

Background： This gene is a member of the family of dihydroxyacetone kinases, which have a protein structure distinct from other kinases. The product of this gene phosphorylates dihydroxyacetone, and also catalyzes the formation of riboflavin 4',5'-phosphate (aka cyclin FMN) from FAD. Several alternatively spliced transcript variants have been identified, but the full-length nature of only one has been determined. [provided by RefSeq, Jul 2008],

Function：catalytic activity:ATP + glycerone = ADP + glycerone phosphate.,catalytic activity:FAD = AMP + riboflavin cyclic-4',5'-phosphate.,cofactor:Magnesium.,cofactor:Manganese or cobalt; for FAD-AMP lyase activity.,enzyme regulation:Each activity is inhibited by the substrate(s) of the other.,function:Catalyzes both the phosphorylation of dihydroxyacetone and the splitting of ribonucleoside diphosphate-X compounds among which FAD is the best substrate.,similarity:Belongs to the dihydroxyacetone kinase (DAK) family.,similarity:Contains 1 DAK1 (dihydroxyacetone kinase subunit 1) domain.,similarity:Contains 1 DAK2 (dihydroxyacetone kinase subunit 2) domain.,subunit:Homodimer.,

Subcellular Location：nucleus,cytosol,extracellular exosome,

Expression：Detected in erythrocytes (at protein level).