Target：DGLA

Fields：Retrograde endocannabinoid signaling;Aldosterone synthesis and secretion

Gene Name：DAGLA C11orf11 KIAA0659 NSDDR

Protein Name：Sn1-specific diacylglycerol lipase alpha (DGL-alpha) (EC 3.1.1.-) (Neural stem cell-derived dendrite regulator)

Human Gene Id：747

Human Swiss Prot No：Q9Y4D2

Mouse Swiss Prot No：Q6WQJ1

Rat Swiss Prot No：Q5YLM1

Immunogen：Synthesized peptide derived from human protein . at AA range: 900-980

Specificity：DGLA Polyclonal Antibody detects endogenous levels of protein.

Formulation：Liquid in PBS containing 50% glycerol, and 0.02% sodium azide.

Source：Polyclonal, Rabbit,IgG

Dilution：WB 1:500-2000 ELISA 1:5000-20000

Purification：The antibody was affinity-purified from rabbit antiserum by affinity-chromatography using epitope-specific immunogen.

Concentration：1 mg/ml

Storage Stability：-15°C to -25°C/1 year(Do not lower than -25°C)

Observed Band(KD)：114kD

Background： This gene encodes a diacylglycerol lipase. The encoded enzyme is involved in the biosynthesis of the endocannabinoid 2-arachidonoyl-glycerol.[provided by RefSeq, Nov 2010],

Function：cofactor:Calcium.,enzyme regulation:Inhibited by p-hydroxy-mercuri-benzoate and HgCl(2), but not to PMSF. Also inhibited by RHC80267, a drug that blocks 2-AG formation.,function:Catalyzes the hydrolysis of diacylglycerol (DAG) to 2-arachidonoyl-glycerol (2-AG), the most abundant endocannabinoid in tissues. Required for axonal growth during development and for retrograde synaptic signaling at mature synapses.,similarity:Belongs to the AB hydrolase superfamily. Lipase family.,tissue specificity:Highly expressed in brain and pancreas.,

Subcellular Location：Cell membrane ; Multi-pass membrane protein . Cell junction, synapse, postsynaptic density membrane ; Multi-pass membrane protein . Early endosome membrane ; Multi-pass membrane protein . Cell projection, dendritic spine membrane ; Multi-pass membrane protein . Cycles between the cell surface and an intracellular endosomal compartment. Internalized by early endosomes via a clathrin-independent pathway before transport back to the postsynaptic membrane surface in a PKC-dependent manner. .

Expression：Highly expressed in brain and pancreas.