Target：DEF1
Fields：NOD-like receptor signaling pathway;Staphylococcus aureus infection;Transcriptional misregulation in cancer
Gene Name：DEFA1
Protein Name：Neutrophil defensin 1
Human Gene Id：1667
Human Swiss Prot No：P59665
Immunogen：The antiserum was produced against synthesized peptide derived from human Defensin alpha1. AA range:3-52
Specificity：Defensin α1 Polyclonal Antibody detects endogenous levels of Defensin α1 protein.
Formulation：Liquid in PBS containing 50% glycerol, 0.5% BSA and 0.02% sodium azide.
Source：Polyclonal, Rabbit,IgG
Dilution：IHC 1:100 - 1:300. ELISA: 1:40000.. IF 1:50-200
Purification：The antibody was affinity-purified from rabbit antiserum by affinity-chromatography using epitope-specific immunogen.
Concentration：1 mg/ml
Storage Stability：-15°C to -25°C/1 year(Do not lower than -25°C)
Other Name：DEFA1;DEF1;DEFA2;MRS;DEFA1B;Neutrophil defensin 1;Defensin; alpha 1;HNP-1;HP-1;HP1
Observed Band(KD)：11kD
Background：defensin alpha 1(DEFA1) Homo sapiens Defensins are a family of antimicrobial and cytotoxic peptides thought to be involved in host defense. They are abundant in the granules of neutrophils and also found in the epithelia of mucosal surfaces such as those of the intestine, respiratory tract, urinary tract, and vagina. Members of the defensin family are highly similar in protein sequence and distinguished by a conserved cysteine motif. The protein encoded by this gene, defensin, alpha 1, is found in the microbicidal granules of neutrophils and likely plays a role in phagocyte-mediated host defense. Several alpha defensin genes are clustered on chromosome 8. This gene differs from defensin, alpha 3 by only one amino acid. This gene and the gene encoding defensin, alpha 3 are both subject to copy number variation. [provided by RefSeq, Oct 2014],
Function：function:Defensin 1 and defensin 2 have antibacterial, fungicide and antiviral activities. Has antimicrobial activity against Gram-negative and Gram-positive bacteria. Defensins are thought to kill microbes by permeabilizing their plasma membrane.,similarity:Belongs to the alpha-defensin family.,subunit:Dimer.,
Subcellular Location：Secreted.
Expression： Liver,Lung,
