Target：DEC2

Fields：Circadian rhythm

Gene Name：BHLHE41

Protein Name：Class E basic helix-loop-helix protein 41

Human Gene Id：79365

Human Swiss Prot No：Q9C0J9

Mouse Gene Id：79362

Mouse Swiss Prot No：Q99PV5

Rat Swiss Prot No：O35779

Immunogen：The antiserum was produced against synthesized peptide derived from human BHLHB3. AA range:1-50

Specificity：DEC2 Polyclonal Antibody detects endogenous levels of 40879 protein.

Formulation：Liquid in PBS containing 50% glycerol, 0.5% BSA and 0.02% sodium azide.

Source：Polyclonal, Rabbit,IgG

Dilution：WB 1:500 - 1:2000. IHC 1:100 - 1:300. ELISA: 1:40000.. IF 1:50-200

Purification：The antibody was affinity-purified from rabbit antiserum by affinity-chromatography using epitope-specific immunogen.

Concentration：1 mg/ml

Storage Stability：-15°C to -25°C/1 year(Do not lower than -25°C)

Other Name：BHLHE41;BHLHB3;DEC2;SHARP1;Class E basic helix-loop-helix protein 41;bHLHe41;Class B basic helix-loop-helix protein 3;bHLHb3;Differentially expressed in chondrocytes protein 2;hDEC2;Enhancer-of-split and hairy-related protein 1;S

Observed Band(KD)：50kD

Background： This gene encodes a basic helix-loop-helix protein expressed in various tissues. The encoded protein can interact with ARNTL or compete for E-box binding sites in the promoter of PER1 and repress CLOCK/ARNTL's transactivation of PER1. This gene is believed to be involved in the control of circadian rhythm and cell differentiation. Defects in this gene are associated with the short sleep phenotype. [provided by RefSeq, Feb 2014],

Function：function:May be a transcriptional repressor that represses both basal and activated transcription.,similarity:Contains 1 basic helix-loop-helix (bHLH) domain.,similarity:Contains 1 Orange domain.,subunit:Homodimerize.,tissue specificity:Highly expressed in skeletal muscle and brain, moderately expressed in pancreas and heart, weakly expressed in placenta, lung, liver and kidney.,

Subcellular Location：Nucleus .

Expression：Highly expressed in skeletal muscle and brain, moderately expressed in pancreas and heart, weakly expressed in placenta, lung, liver and kidney.