Target：ANT3

Fields：Calcium signaling pathway;cGMP-PKG signaling pathway;Necroptosis;Cellular senescence;Neutrophil extracellular trap formation;Alzheimer disease;Parkinson disease;Huntington disease;Spinocerebellar ataxia;Prion disease;Pathways of neurodegeneration - multiple diseases;Influenza A;Human T-cell leukemia virus 1 infection;Chemical carcinogenesis - reactive oxygen species;Diabetic cardiomyopathy

Gene Name：SLC25A6

Protein Name：ADP/ATP translocase 3

Human Gene Id：293

Human Swiss Prot No：P12236

Immunogen：The antiserum was produced against synthesized peptide derived from human SLC25A6. AA range:121-170

Specificity：ANT3 Polyclonal Antibody detects endogenous levels of ANT3 protein.

Formulation：Liquid in PBS containing 50% glycerol, 0.5% BSA and 0.02% sodium azide.

Source：Polyclonal, Rabbit,IgG

Dilution：WB 1:500 - 1:2000. IHC 1:100 - 1:300. ELISA: 1:40000.. IF 1:50-200

Purification：The antibody was affinity-purified from rabbit antiserum by affinity-chromatography using epitope-specific immunogen.

Concentration：1 mg/ml

Storage Stability：-15°C to -25°C/1 year(Do not lower than -25°C)

Other Name：SLC25A6;ANT3;CDABP0051;ADP/ATP translocase 3;ADP;ATP carrier protein 3;ADP,ATP carrier protein, isoform T2;ANT 2;Adenine nucleotide translocator 3;ANT 3;Solute carrier family 25 member 6

Observed Band(KD)：32kD

Background： This gene is a member of the mitochondrial carrier subfamily of solute carrier protein genes. The product of this gene functions as a gated pore that translocates ADP from the cytoplasm into the mitochondrial matrix and ATP from the mitochondrial matrix into the cytoplasm. The protein is implicated in the function of the permability transition pore complex (PTPC), which regulates the release of mitochondrial products that induce apoptosis. The human genome contains several non-transcribed pseudogenes of this gene. [provided by RefSeq, Jun 2013],

Function：function:Catalyzes the exchange of ADP and ATP across the mitochondrial inner membrane. May participate in the formation of the permeability transition pore complex (PTPC) responsible for the release of mitochondrial products that triggers apoptosis.,miscellaneous:The gene encoding for this protein is located in the pseudoautosomal region 1 (PAR1) of X and Y chromosomes.,miscellaneous:The transmembrane helices are not perpendicular to the plane of the membrane, but cross the membrane at an angle. Odd-numbered transmembrane helices exhibit a sharp kink, due to the presence of a conserved proline residue.,similarity:Belongs to the mitochondrial carrier family.,similarity:Contains 3 Solcar repeats.,subunit:Homodimer. Interacts with influenza A virus PB1-F2 protein and HIV-1 Vpr.,

Subcellular Location：Mitochondrion inner membrane ; Multi-pass membrane protein . Membrane ; Multi-pass membrane protein . The complex formed with ARL2BP, ARL2 and SLC25A6/ANT3 is expressed in mitochondria (By similarity). May localize to non-mitochondrial membranes (By similarity). .

Expression：Expressed in erythrocytes (at protein level).