Target：DDX24

Gene Name：DDX24

Protein Name：ATP-dependent RNA helicase DDX24

Human Gene Id：57062

Human Swiss Prot No：Q9GZR7

Mouse Swiss Prot No：Q9ESV0

Immunogen：The antiserum was produced against synthesized peptide derived from human DDX24. AA range:41-90

Specificity：DDX24 Polyclonal Antibody detects endogenous levels of DDX24 protein.

Formulation：Liquid in PBS containing 50% glycerol, 0.5% BSA and 0.02% sodium azide.

Source：Polyclonal, Rabbit,IgG

Dilution：IHC 1:100 - 1:300. ELISA: 1:40000.. IF 1:50-200

Purification：The antibody was affinity-purified from rabbit antiserum by affinity-chromatography using epitope-specific immunogen.

Concentration：1 mg/ml

Storage Stability：-15°C to -25°C/1 year(Do not lower than -25°C)

Other Name：DDX24;ATP-dependent RNA helicase DDX24;DEAD box protein 24

Observed Band(KD)：120kD

Background： DEAD box proteins, characterized by the conserved motif Asp-Glu-Ala-Asp (DEAD), are putative RNA helicases. They are implicated in a number of cellular processes involving alteration of RNA secondary structure such as translation initiation, nuclear and mitochondrial splicing, and ribosome and spliceosome assembly. Based on their distribution patterns, some members of this family are believed to be involved in embryogenesis, spermatogenesis, and cellular growth and division. This gene encodes a DEAD box protein, which shows little similarity to any of the other known human DEAD box proteins, but shows a high similarity to mouse Ddx24 at the amino acid level. [provided by RefSeq, Jul 2008],

Function：function:ATP-dependent RNA helicase .,PTM:Phosphorylated upon DNA damage, probably by ATM or ATR.,similarity:Belongs to the DEAD box helicase family.,similarity:Belongs to the DEAD box helicase family. DDX24/MAK5 subfamily.,similarity:Contains 1 helicase ATP-binding domain.,similarity:Contains 1 helicase C-terminal domain.,tissue specificity:Ubiquitous. Most abundant in heart and brain, but with lowest levels in thymus and small intestine.,

Subcellular Location：nucleolus,membrane,

Expression：Ubiquitous. Most abundant in heart and brain, but with lowest levels in thymus and small intestine.