Target：DcR3

Fields：Cytokine-cytokine receptor interaction

Gene Name：TNFRSF6B

Protein Name：Tumor necrosis factor receptor superfamily member 6B

Human Gene Id：8771

Human Swiss Prot No：O95407

Immunogen：The antiserum was produced against synthesized peptide derived from human TNFRSF6B. AA range:251-300

Specificity：DcR3 Polyclonal Antibody detects endogenous levels of DcR3 protein.

Formulation：Liquid in PBS containing 50% glycerol, 0.5% BSA and 0.02% sodium azide.

Source：Polyclonal, Rabbit,IgG

Dilution：WB 1:500 - 1:2000. IHC 1:100 - 1:300. IF 1:200 - 1:1000. ELISA: 1:5000. Not yet tested in other applications.

Purification：The antibody was affinity-purified from rabbit antiserum by affinity-chromatography using epitope-specific immunogen.

Concentration：1 mg/ml

Storage Stability：-15°C to -25°C/1 year(Do not lower than -25°C)

Other Name：TNFRSF6B;DCR3;TR6;Tumor necrosis factor receptor superfamily member 6B;Decoy receptor 3;DcR3;Decoy receptor for Fas ligand;M68

Observed Band(KD)：32kD

Background： This gene belongs to the tumor necrosis factor receptor superfamily. The encoded protein is postulated to play a regulatory role in suppressing FasL- and LIGHT-mediated cell death. It acts as a decoy receptor that competes with death receptors for ligand binding. Over-expression of this gene has been noted in gastrointestinal tract tumors. Read-through transcription into this gene from the neighboring upstream gene, which encodes regulator of telomere elongation helicase 1 (RTEL1), generates a non-coding transcript. [provided by RefSeq, Feb 2011],

Function：alternative products:Additional isoforms seem to exist,function:ATP-dependent DNA helicase required to suppress inappropriate homologous recombination, thereby playing a central role DNA repair and in the maintenance of genomic stability. Antagonizes homologous recombination by promoting the disassembly of D loop recombination intermediates. Also required to regulate telomere length; probably due to its anti-recombinase function.,function:Decoy receptor for the cytotoxic ligands TNFS14/LIGHT and TNFSF6/FASL. Protects against apoptosis.,miscellaneous:Amplified in gastric tumors.,similarity:Belongs to the helicase family. RAD3/XPD subfamily.,similarity:Contains 1 helicase ATP-binding domain.,similarity:Contains 4 TNFR-Cys repeats.,tissue specificity:Detected in fetal lung, brain and liver. Detected in adult stomach, spinal cord, lymph node, trachea, spleen, colon and lung. Highly expressed

Subcellular Location：Secreted.

Expression：Detected in fetal lung, brain and liver. Detected in adult stomach, spinal cord, lymph node, trachea, spleen, colon and lung. Highly expressed in several primary tumors from colon, stomach, rectum, esophagus and in SW480 colon carcinoma cells.