Target：DCOR
Fields：Arginine and proline metabolism;Glutathione metabolism;Metabolic pathways
Gene Name：ODC1
Protein Name：Ornithine decarboxylase (ODC) (EC 4.1.1.17)
Human Gene Id：4953
Human Swiss Prot No：P11926
Mouse Swiss Prot No：P00860
Rat Swiss Prot No：P09057
Immunogen：Synthesized peptide derived from human protein . at AA range: 250-330
Specificity：DCOR Polyclonal Antibody detects endogenous levels of protein.
Formulation：Liquid in PBS containing 50% glycerol, and 0.02% sodium azide.
Source：Polyclonal, Rabbit,IgG
Dilution：WB 1:500-2000 ELISA 1:5000-20000
Purification：The antibody was affinity-purified from rabbit antiserum by affinity-chromatography using epitope-specific immunogen.
Concentration：1 mg/ml
Storage Stability：-15°C to -25°C/1 year(Do not lower than -25°C)
Observed Band(KD)：50kD
Background：ornithine decarboxylase 1(ODC1) Homo sapiens This gene encodes the rate-limiting enzyme of the polyamine biosynthesis pathway which catalyzes ornithine to putrescine. The activity level for the enzyme varies in response to growth-promoting stimuli and exhibits a high turnover rate in comparison to other mammalian proteins. Originally localized to both chromosomes 2 and 7, the gene encoding this enzyme has been determined to be located on 2p25, with a pseudogene located on 7q31-qter. Multiple alternatively spliced transcript variants encoding distinct isoforms have been identified. [provided by RefSeq, Dec 2013],
Function：catalytic activity:L-ornithine = putrescine + CO(2).,cofactor:Pyridoxal phosphate.,enzyme regulation:Inhibited by S-nitrosylation.,online information:Ornithine decarboxylase entry,pathway:Amine and polyamine biosynthesis; putrescine biosynthesis via L-ornithine pathway; putrescine from L-ornithine: step 1/1.,PTM:S-Nitrosylation inhibits the enzyme. S-Nitrosylated in vitro on 4 cysteine residues.,similarity:Belongs to the Orn/Lys/Arg decarboxylase class-II family.,subunit:Homodimer.,
Subcellular Location：cytoplasm,cytosol,perinuclear region of cytoplasm,
Expression： Esophagus,Lymph,Testis,
