Target：DCAMKL2

Gene Name：DCLK2

Protein Name：Serine/threonine-protein kinase DCLK2

Human Gene Id：166614

Human Swiss Prot No：Q8N568

Mouse Gene Id：70762

Mouse Swiss Prot No：Q6PGN3

Immunogen：The antiserum was produced against synthesized peptide derived from human DCLK2. AA range:1-50

Specificity：DCAMKL2 Polyclonal Antibody detects endogenous levels of DCAMKL2 protein.

Formulation：Liquid in PBS containing 50% glycerol, 0.5% BSA and 0.02% sodium azide.

Source：Polyclonal, Rabbit,IgG

Dilution：WB 1:500 - 1:2000. IF 1:200 - 1:1000. ELISA: 1:10000. Not yet tested in other applications.

Purification：The antibody was affinity-purified from rabbit antiserum by affinity-chromatography using epitope-specific immunogen.

Concentration：1 mg/ml

Storage Stability：-15°C to -25°C/1 year(Do not lower than -25°C)

Other Name：DCLK2;DCAMKL2;DCDC3B;DCK2;Serine/threonine-protein kinase DCLK2;CaMK-like CREB regulatory kinase 2;CL2;CLICK-II;CLICK2;Doublecortin domain-containing protein 3B;Doublecortin-like and CAM kinase-like 2;Doublecortin-like kinase 2

Observed Band(KD)：83kD

Background： This gene encodes a member of the protein kinase superfamily and the doublecortin family. The protein encoded by this gene contains two N-terminal doublecortin domains, which bind microtubules and regulate microtubule polymerization, a C-terminal serine/threonine protein kinase domain, which shows substantial homology to Ca2+/calmodulin-dependent protein kinase, and a serine/proline-rich domain in between the doublecortin and the protein kinase domains, which mediates multiple protein-protein interactions. The microtubule-polymerizing activity of the encoded protein is independent of its protein kinase activity. Mouse studies show that the DCX gene, another family member, and this gene share function in the establishment of hippocampal organization and that their absence results in a severe epileptic phenotype and lethality, as described in human patients with lissencephaly. Multiple alterna

Function：catalytic activity:ATP + a protein = ADP + a phosphoprotein.,similarity:Belongs to the protein kinase superfamily.,similarity:Belongs to the protein kinase superfamily. CAMK Ser/Thr protein kinase family. CaMK subfamily.,similarity:Contains 1 protein kinase domain.,similarity:Contains 2 doublecortin domains.,

Subcellular Location：Cytoplasm, cytoskeleton. Colocalizes with microtubules. .

Expression：Expressed in the brain, heart and eyes.