Target：Cytokeratin 16

Fields：Estrogen signaling pathway;Staphylococcus aureus infection

Gene Name：KRT16

Protein Name：Keratin type I cytoskeletal 16

Human Gene Id：3868

Human Swiss Prot No：P08779

Mouse Gene Id：16666

Mouse Swiss Prot No：Q9Z2K1

Immunogen：The antiserum was produced against synthesized peptide derived from human Keratin 16. AA range:421-470

Specificity：Cytokeratin 16 Polyclonal Antibody detects endogenous levels of Cytokeratin 16 protein.

Formulation：Liquid in PBS containing 50% glycerol, 0.5% BSA and 0.02% sodium azide.

Source：Polyclonal, Rabbit,IgG

Dilution：WB 1:500 - 1:2000. IHC 1:100 - 1:300. ELISA: 1:10000.. IF 1:50-200

Purification：The antibody was affinity-purified from rabbit antiserum by affinity-chromatography using epitope-specific immunogen.

Concentration：1 mg/ml

Storage Stability：-15°C to -25°C/1 year(Do not lower than -25°C)

Other Name：KRT16;KRT16A;Keratin; type I cytoskeletal 16;Cytokeratin-16;CK-16;Keratin-16;K16

Observed Band(KD)：52kD

Background： The protein encoded by this gene is a member of the keratin gene family. The keratins are intermediate filament proteins responsible for the structural integrity of epithelial cells and are subdivided into cytokeratins and hair keratins. Most of the type I cytokeratins consist of acidic proteins which are arranged in pairs of heterotypic keratin chains and are clustered in a region of chromosome 17q12-q21. This keratin has been coexpressed with keratin 14 in a number of epithelial tissues, including esophagus, tongue, and hair follicles. Mutations in this gene are associated with type 1 pachyonychia congenita, non-epidermolytic palmoplantar keratoderma and unilateral palmoplantar verrucous nevus. [provided by RefSeq, Jul 2008],

Function：disease:Defects in KRT16 are a cause of pachyonychia congenita type 1 (PC1) [MIM:167200]; also known as Jadassohn-Lewandowsky syndrome. PC1 is an autosomal dominant ectodermal dysplasia characterized by hypertrophic nail dystrophy resulting in onchyogryposis (thickening and increase in curvature of the nail), palmoplantar keratoderma, follicular hyperkeratosis, and oral leukokeratosis. Hyperhidrosis of the hands and feet is usually present.,disease:Defects in KRT16 are a cause of unilateral palmoplantar verrucous nevus (UPVN) [MIM:144200]. UPVN is characterized by a localized thickening of the skin in parts of the right palm and the right sole.,disease:Defects in KRT16 are the cause of palmoplantar keratoderma non-epidermolytic (NEPPK) [MIM:600962]. NEPKK is a dermatological disorder characterized by focal palmoplantar keratoderma with oral, genital, and follicular lesions.,disease:KRT16

Subcellular Location：nucleus,cytoskeleton,intermediate filament,extracellular exosome,

Expression：Expressed in the corneal epithelium (at protein level).