Target：Cytochrome b5

Gene Name：CYB5A

Protein Name：Cytochrome b5

Human Gene Id：1528

Human Swiss Prot No：P00167

Mouse Gene Id：109672

Mouse Swiss Prot No：P56395

Rat Gene Id：64001

Rat Swiss Prot No：P00173

Immunogen：The antiserum was produced against synthesized peptide derived from human CYB5. AA range:61-110

Specificity：Cytochrome b5 Polyclonal Antibody detects endogenous levels of Cytochrome b5 protein.

Formulation：Liquid in PBS containing 50% glycerol, 0.5% BSA and 0.02% sodium azide.

Source：Polyclonal, Rabbit,IgG

Dilution：WB 1:500 - 1:2000. IHC 1:100 - 1:300. IF 1:200 - 1:1000. ELISA: 1:5000. Not yet tested in other applications.

Purification：The antibody was affinity-purified from rabbit antiserum by affinity-chromatography using epitope-specific immunogen.

Concentration：1 mg/ml

Storage Stability：-15°C to -25°C/1 year(Do not lower than -25°C)

Other Name：CYB5A;CYB5;Cytochrome b5;Microsomal cytochrome b5 type A;MCB5

Observed Band(KD)：15kD

Background： The protein encoded by this gene is a membrane-bound cytochrome that reduces ferric hemoglobin (methemoglobin) to ferrous hemoglobin, which is required for stearyl-CoA-desaturase activity. Defects in this gene are a cause of type IV hereditary methemoglobinemia. Three transcript variants encoding different isoforms have been found for this gene. [provided by RefSeq, Jun 2010],

Function：disease:Defects in CYB5A are the cause of type IV hereditary methemoglobinemia [MIM:250790].,function:Cytochrome b5 is a membrane bound hemoprotein which function as an electron carrier for several membrane bound oxygenases.,similarity:Belongs to the cytochrome b5 family.,similarity:Contains 1 cytochrome b5 heme-binding domain.,

Subcellular Location：[Isoform 1]: Endoplasmic reticulum membrane; Single-pass membrane protein; Cytoplasmic side. Microsome membrane; Single-pass membrane protein; Cytoplasmic side.; [Isoform 2]: Cytoplasm.

Expression： Erythrocyte,Liver,Spleen,Uterus,