Target：CysLTR2

Fields：Calcium signaling pathway;Neuroactive ligand-receptor interaction

Gene Name：CYSLTR2

Protein Name：Cysteinyl leukotriene receptor 2

Human Gene Id：57105

Human Swiss Prot No：Q9NS75

Mouse Swiss Prot No：Q920A1

Immunogen：The antiserum was produced against synthesized peptide derived from human CYSLTR2. AA range:281-330

Specificity：CysLTR2 Polyclonal Antibody detects endogenous levels of CysLTR2 protein.

Formulation：Liquid in PBS containing 50% glycerol, 0.5% BSA and 0.02% sodium azide.

Source：Polyclonal, Rabbit,IgG

Dilution：WB 1:500 - 1:2000. IF 1:200 - 1:1000. ELISA: 1:20000. Not yet tested in other applications.

Purification：The antibody was affinity-purified from rabbit antiserum by affinity-chromatography using epitope-specific immunogen.

Concentration：1 mg/ml

Storage Stability：-15°C to -25°C/1 year(Do not lower than -25°C)

Other Name：CYSLTR2;CYSLT2;CYSLT2R;PSEC0146;Cysteinyl leukotriene receptor 2;CysLTR2;G-protein coupled receptor GPCR21;hGPCR21;G-protein coupled receptor HG57;HPN321

Observed Band(KD)：40kD

Background： The cysteinyl leukotrienes LTC4, LTD4, and LTE4 are important mediators of human bronchial asthma. Pharmacologic studies have determined that cysteinyl leukotrienes activate at least 2 receptors, the protein encoded by this gene and CYSLTR1. This encoded receptor is a member of the superfamily of G protein-coupled receptors. It seems to play a major role in endocrine and cardiovascular systems. [provided by RefSeq, Jul 2008],

Function：function:Receptor for cysteinyl leukotrienes. The response is mediated via a G-protein that activates a phosphatidylinositol-calcium second messenger system. Stimulation by BAY u9773, a partial agonist, induces specific contractions of pulmonary veins and might also have an indirect role in the relaxation of the pulmonary vascular endothelium. The rank order of affinities for the leukotrienes is LTC4 = LTD4 LTE4.,similarity:Belongs to the G-protein coupled receptor 1 family.,tissue specificity:Widely expressed, with highest levels in the heart, placenta, spleen, peripheral blood leukocytes and adrenal gland. In lung, expressed in the interstitial macrophages, and slightly in smooth muscle cells.,

Subcellular Location：Cell membrane; Multi-pass membrane protein.

Expression：Widely expressed, with highest levels in the heart, placenta, spleen, peripheral blood leukocytes and adrenal gland. In lung, expressed in the interstitial macrophages, and slightly in smooth muscle cells.